INT182627

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.27
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 82.52 Quite High
Inflammation 24 81.72 Quite High
Pain 2 45.92 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 8 99.82 Very High Very High Very High
Cancer 22 99.36 Very High Very High Very High
Microsatellite Instability 4 96.96 Very High Very High Very High
Genomic Instability 4 93.08 High High
Skin Cancer 16 82.40 Quite High
INFLAMMATION 22 81.72 Quite High
Oral Lichen Planus 70 72.28 Quite High
Malignant Neoplastic Disease 14 66.72 Quite High
Prostate Cancer 2 54.04 Quite High
Death 2 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A distinct proportion of sporadic (and almost all hereditary) non-polyposis colorectal cancers exhibit hMSH2 gene alterations.
Regulation (alterations) of hMSH2 associated with colon cancer
1) Confidence 0.26 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.50 Pain Relevance 0.06
MMR genes, including hMSH2, hMLH1, hMSH3, hMPS1, hPMS2 and GTBP/hMSH6 are very important in distinguishing and repairing misparing and slippage errors in DNA synthesis.
Regulation (important) of hMSH2
2) Confidence 0.26 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.78 Pain Relevance 0.12

General Comments

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