INT182629

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 5.24
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
macrophage 1
hematopoietic system 1
hilus 1
HSC 1
kidney 1
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 97 99.96 Very High Very High Very High
Hippocampus 116 98.16 Very High Very High Very High
cytokine 59 97.36 Very High Very High Very High
antagonist 42 88.76 High High
GABAergic 4 86.56 High High
ischemia 12 84.80 Quite High
Inflammation 27 84.64 Quite High
cerebral cortex 9 82.96 Quite High
Central nervous system 21 61.88 Quite High
Spinal cord 6 61.04 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 80 97.56 Very High Very High Very High
Breast Cancer 35 96.00 Very High Very High Very High
Adhesions 16 93.08 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 335 92.68 High High
Cancer 137 89.44 High High
Convulsion 132 89.16 High High
Status Epilepticus 57 88.72 High High
Cv Unclassified Under Development 12 84.80 Quite High
INFLAMMATION 32 84.64 Quite High
Metastasis 106 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A CXC chemokine, PBSF/SDF-1, has recently been identified to be a ligand for fusin 60,61 The identification of CCR-5 as the co-receptor for macrophage-tropic viruses is consistent with an earlier report identifying the CCR-5 ligands (RANTES, MIP-1?
PBSF/SDF-1 Binding (receptor) of in macrophage associated with chemokine
1) Confidence 0.36 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 0.78 Pain Relevance 0.09
This was done either by blocking endogenous SDF-1, blocking BMC-associated CXCR4 or increasing locally SDF-1 [11,12,18,21,26].
CXCR4 Binding (associated) of
2) Confidence 0.30 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.34 Pain Relevance 0.04
To determine whether CXCL12-induced migration is mediated via CXCR4 receptors, we blocked CXCR4 receptors with a small pharmacological inhibitor, AMD3100 [40].
CXCR4 Binding (receptors) of
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.08
CXCL12 signaling via its primary receptor, CXCR4, guides migrating granule neural precursors from the hilus into the DG during development [15], [16].
CXCR4 Binding (receptor) of in hilus
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.40 Pain Relevance 0.42
In conclusion, our initial hypothesis that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney is not supported by the results in this report.
CXCR4 Binding (interactions) of in kidney
5) Confidence 0.29 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.14 Pain Relevance 0.04
Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney.
CXCR4 Binding (interactions) of in HSC
6) Confidence 0.29 Published 2009 Journal Nephrology Dialysis Transplantation Section Abstract Doc Link PMC2698094 Disease Relevance 0.14 Pain Relevance 0.04
To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].
CXCR4 Spec (examined) Binding (bind) of
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.11
Of these, only vascular endothelial growth factor (VEGF) and CXCR4, showed additive responses to TGF-?
CXCR4 Binding (only) of
8) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.60 Pain Relevance 0
The bridging sheet interacts with the N-terminus of CCR5 or CXCR4.
CXCR4 Binding (interacts) of
9) Confidence 0.21 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.48 Pain Relevance 0.12
This finding is consistent with known GPCR biology and confirms that internalized CXCR4 in Gag expressing cells is desensitized and does not signal.

?

CXCR4 Neg (not) Binding (signal.) of
10) Confidence 0.21 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.28 Pain Relevance 0
This finding is consistent with known GPCR biology and confirms that internalized CXCR4 in Gag expressing cells is desensitized and does not signal.

?

CXCR4 Binding (internalized) of
11) Confidence 0.21 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.28 Pain Relevance 0
, PE conjugated; Biolegend, San Diego, CA, USA) and CXCR4 (2B11/CXCR4, rat IgG2b ?
CXCR4 Binding (conjugated) of
12) Confidence 0.21 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.14
, PE conjugated; Biolegend, San Diego, CA, USA) and CXCR4 (2B11/CXCR4, rat IgG2b ?
CXCR4 Binding (conjugated) of
13) Confidence 0.21 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.14
The V3 loop, on the other hand, mediates interactions with the second extracellular loop (ECL2) of CCR5 or CXCR4 and is the principle determinant of coreceptor specificity.
CXCR4 Spec (determinant) Binding (interactions) of
14) Confidence 0.17 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.45 Pain Relevance 0.11
A recent study has demonstrated that in the hematopoietic system Podocalyxin co-associates with the SDF-1 receptor CXCR4 thus modulating the biochemical signaling response to this cytokine [49].
SDF-1 receptor Binding (associates) of in hematopoietic system associated with cytokine
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.36 Pain Relevance 0.12

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