INT182666

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 9.01
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
liver 1
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 70 100.00 Very High Very High Very High
Inflammation 119 99.88 Very High Very High Very High
Bile 335 99.16 Very High Very High Very High
fibrosis 70 98.12 Very High Very High Very High
visual analogue scale 8 97.12 Very High Very High Very High
corticosteroid 20 89.60 High High
pruritus 70 84.28 Quite High
Kinase C 5 75.32 Quite High
fluoxetine 5 63.60 Quite High
sSRI 10 62.52 Quite High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 1272 100.00 Very High Very High Very High
INFLAMMATION 117 99.88 Very High Very High Very High
Primary Sclerosing Cholangitis 59 99.80 Very High Very High Very High
Liver Disease 120 99.34 Very High Very High Very High
Fibrosis 80 98.12 Very High Very High Very High
Autoimmune Disease 150 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 10 96.00 Very High Very High Very High
Fatigue 124 95.52 Very High Very High Very High
Osteoporosis 55 93.84 High High
Hepatitis Virus Infection 10 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AE2 expression and biliary bicarbonate secretion is usually diminished in PBC [241].
Negative_regulation (diminished) of PBC associated with biliary liver cirrhosis
1) Confidence 0.38 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.45 Pain Relevance 0.15
Treatment of the underlying liver disease with UDCA does not prevent bone loss in PBC [317, 318].
Negative_regulation (loss) of PBC in liver associated with liver disease and biliary liver cirrhosis
2) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.82 Pain Relevance 0.19
An alternative but complementary concept for loss of self-tolerance in PBC is the idea of underlying immune deficits.
Negative_regulation (loss) of PBC associated with biliary liver cirrhosis and tolerance
3) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.54 Pain Relevance 0.18
Loss of self-tolerance in PBC
Negative_regulation (Loss) of PBC associated with biliary liver cirrhosis and tolerance
4) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 2.43 Pain Relevance 0.26
In PBC, expression of the hepatic AE2 and biliary bicarbonate secretion by AE2 are impaired [240, 241].
Negative_regulation (impaired) of PBC associated with biliary liver cirrhosis
5) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.41 Pain Relevance 0.32
Valine, isoleucine, leucine were significantly decreased in PBC and PSC.
Negative_regulation (decreased) of PBC associated with biliary liver cirrhosis and primary sclerosing cholangitis
6) Confidence 0.11 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1079813 Disease Relevance 2.36 Pain Relevance 0.05

General Comments

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