INT182667

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 26
Disease Relevance 40.75
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
liver 3
lymph nodes 1
Plasma 1
Thyroid 1
immune system 1
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 334 99.98 Very High Very High Very High
cva 47 99.92 Very High Very High Very High
Crohn's disease 74 99.80 Very High Very High Very High
Inflammation 426 99.76 Very High Very High Very High
tolerance 234 99.68 Very High Very High Very High
Bile 1186 97.20 Very High Very High Very High
Sicca syndrome 31 96.96 Very High Very High Very High
methotrexate 26 90.64 High High
depression 21 87.52 High High
fibrosis 254 85.92 High High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 4842 100.00 Very High Very High Very High
Disease 997 100.00 Very High Very High Very High
Fatigue 465 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 269 100.00 Very High Very High Very High
Disease Susceptibility 6 100.00 Very High Very High Very High
Pruritus 366 99.98 Very High Very High Very High
Hemorrhage 57 99.92 Very High Very High Very High
Inflammatory Bowel Disease 115 99.76 Very High Very High Very High
Celiac Disease 62 99.76 Very High Very High Very High
Systemic Lupus Erythematosus 84 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic insufficiency and celiac disease, which are associated with PBC [69–71], may further aggravate malabsorption.
PBC Binding (associated) of associated with biliary liver cirrhosis, celiac disease and exocrine pancreatic insufficiency
1) Confidence 0.31 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 2.18 Pain Relevance 0.25
Furthermore, various infectious agents have been associated with PBC in humans, although direct experimental evidence for their role in the pathogenesis is limited.
PBC Binding (associated) of associated with biliary liver cirrhosis
2) Confidence 0.31 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.04 Pain Relevance 0
Pruritus PBC is more frequently associated with pruritus than other chronic cholestatic liver diseases.
PBC Binding (associated) of in liver associated with liver disease, biliary liver cirrhosis and pruritus
3) Confidence 0.31 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.97 Pain Relevance 0.25
Unlike other cell types [211] for which autoantibody recognition of PDC-E2 is abrogated during apoptosis, probably by glutathiolation of the lysine–lipoyl moiety of PDC-E2, the antigenicity of PDC-E2 persists in the apoptotic BECs in which glutathiolation does not occur [211, 212].
PDC-E2 Binding (recognition) of associated with apoptosis
4) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.98 Pain Relevance 0.06
II or IL-2 receptor or the AE2, gives rise to histologic and serologic changes mimicking PBC in different animal models and may be contributing to susceptibility for PBC in human.
PBC Binding (contributing) of associated with biliary liver cirrhosis
5) Confidence 0.24 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.12 Pain Relevance 0
An alternative infectious agent has recently been proposed as trigger of PBC when a human retrovirus was identified both in liver tissue and hilar lymph nodes from PBC patients.
PBC Binding (trigger) of in lymph nodes associated with biliary liver cirrhosis
6) Confidence 0.24 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.90 Pain Relevance 0
Long-term controlled trials are required to define whether combination of UDCA with budesonide provides a significant benefit in patients with early-stage PBC inadequately responding to UDCA monotherapy.
PBC Binding (responding) of associated with biliary liver cirrhosis
7) Confidence 0.24 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.53 Pain Relevance 0.07
The exact pathogenetic mechanisms responsible for BEC damage in PBC remain unknown.
PBC Binding (damage) of associated with biliary liver cirrhosis
8) Confidence 0.24 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.97 Pain Relevance 0.23
and of cytotoxic T lymphocyte antigen 4 (CTLA-4), a key regulator of the adaptive immune system, have been repeatedly associated with susceptibility to different autoimmune diseases (such as type I diabetes mellitus and systemic lupus erythematosus) and were also associated with PBC [104–109].
PBC Binding (associated) of in immune system associated with biliary liver cirrhosis, autoimmune disease, diabetes mellitus and systemic lupus erythematosus
9) Confidence 0.24 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.01 Pain Relevance 0.03
PBC is associated with other autoimmune diseases such as Sjogren's syndrome, scleroderma, Raynaud's phenomenon and CREST syndrome and is regarded as an organ specific autoimmune disease.
PBC Binding (associated) of associated with biliary liver cirrhosis, autoimmune disease, syndrome and systemic sclerosis
10) Confidence 0.24 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2266722 Disease Relevance 1.89 Pain Relevance 0.14
Associations between PBC and other autoimmune diseases have been reported.
PBC Binding (Associations) of associated with biliary liver cirrhosis and autoimmune disease
11) Confidence 0.24 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.75 Pain Relevance 0.18
Genetic associations in PBC were shown with major histocompatibility complex encoded genes.
PBC Binding (associations) of associated with biliary liver cirrhosis
12) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.09 Pain Relevance 0.06
More recently, another case–control study provided evidence that there was at least no association between PBC and the occurrence of appendectomy and pointed out the selection bias present in the previous study done in North America [157].
PBC Neg (no) Binding (association) of associated with biliary liver cirrhosis
13) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.54 Pain Relevance 0
PBC is associated with other autoimmune diseases, both within individuals and among families, reflecting the “clustering” characteristic for autoimmunity [183].
PBC Binding (associated) of associated with biliary liver cirrhosis and autoimmune disease
14) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 2.41 Pain Relevance 0.26
In contrast, long-lasting PBC is associated with the occurrence of xanthomata and xanthelasma.
PBC Binding (associated) of associated with biliary liver cirrhosis
15) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.27 Pain Relevance 0.03
Thyroid dysfunction is frequently associated with PBC, often predating its diagnosis [80].
PBC Binding (associated) of in Thyroid associated with biliary liver cirrhosis
16) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 2.34 Pain Relevance 0.15
Celiac disease has been reported in up to 6% of patients [72] and is by far more commonly associated with PBC than inflammatory bowel diseases [83].


PBC Binding (associated) of in bowel associated with biliary liver cirrhosis, celiac disease and inflammation
17) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 2.19 Pain Relevance 0.22
Being one of the first conditions in which specific autoantibodies were recognized, PBC is regarded as a “model autoimmune disease
PBC Binding (recognized) of associated with biliary liver cirrhosis and autoimmune disease
18) Confidence 0.23 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.66 Pain Relevance 0.16
These should be always considered if a patient with PBC has a sudden change in the liver enzyme pattern.
PBC Binding (patient) of in liver associated with biliary liver cirrhosis
19) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.85 Pain Relevance 0.14
A plasma cell infiltrate also characterizes recurrent PBC and distinguishes it from other processes such as drug induced liver injury and acute or chronic rejection [132].
PBC Binding (characterizes) of in liver associated with biliary liver cirrhosis and drug-induced liver injury
20) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.61 Pain Relevance 0.05

General Comments

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