INT182677

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 2.14
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Emx2) DNA binding (Emx2)
Anatomy Link Frequency
patterning 3
precursor cells 1
neural 1
Emx2 (Mus musculus)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 91 84.80 Quite High
Spinal cord 6 82.20 Quite High
imagery 36 73.72 Quite High
cerebral cortex 91 65.12 Quite High
GABAergic 120 56.28 Quite High
Central nervous system 20 47.60 Quite Low
interneuron 24 43.20 Quite Low
projection neuron 3 26.24 Quite Low
tetrodotoxin 6 24.64 Low Low
Action potential 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 298 100.00 Very High Very High Very High
Targeted Disruption 49 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 86.64 High High
Infection 111 57.20 Quite High
Epilepsy 3 47.88 Quite Low
Injury 40 44.56 Quite Low
Neurodegenerative Disease 60 41.28 Quite Low
Stab Wounds 15 9.12 Low Low
Leukemia 11 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While we do not claim the phenotypic differences between C57BL/6J and DBA/2J shown here are evidence of differences in Emx2 expression across these strains, the described shape differences could nonetheless result from polymorphism in early cortical patterning genes or differences in gradients or local enrichments of transcription factors, including Emx2.
Gene_expression (expression) of Emx2 in patterning associated with sprains and strains
1) Confidence 0.78 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.42 Pain Relevance 0.03
For example, Hamasaki et al., [5] caused a caudal over expression of Emx2.
Gene_expression (expression) of Emx2
2) Confidence 0.78 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.28 Pain Relevance 0.04
For example, Hamasaki et al., [5], manipulated expression of the gene Emx2 by transgenic methods.
Gene_expression (expression) of Emx2 associated with targeted disruption
3) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.10 Pain Relevance 0.08
With increasing Emx2 expression, caudal cortical areas increased in size and rostral extent, whereas more rostral areas shifted position and decreased in size.
Gene_expression (expression) of Emx2
4) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.10 Pain Relevance 0.08
While we do not claim the phenotypic differences between C57BL/6J and DBA/2J shown here are evidence of differences in Emx2 expression across these strains, the described shape differences could nonetheless result from polymorphism in early cortical patterning genes or differences in gradients or local enrichments of transcription factors, including Emx2.
Gene_expression (expression) of Emx2 in patterning associated with sprains and strains
5) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.42 Pain Relevance 0.03
Hamasaki et al. [5] demonstrated changes in the position and or size of primary sensory visual, somatosensory, and auditory cortical regions in transgenic mice over expressing the transcription factor Emx2.
Gene_expression (expressing) of Emx2 associated with targeted disruption
6) Confidence 0.57 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079866 Disease Relevance 0.10 Pain Relevance 0
Rostrolateral differences between C57BL/6J and DBA/2J in the PMBSF and in V1 are reminiscent of effects seen in mice over expressing the transcription factor Emx2 (Figure 1 and [5]).
Gene_expression (expressing) of Emx2
7) Confidence 0.53 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.52 Pain Relevance 0.04
However, quantitative RT-PCR showed that there was no difference in the expression of Emx1 or Emx2 mRNAs [38] between astroglial cells cultured adherently or under neurosphere conditions (Figure 10H and 10I).
Gene_expression (expression) of Emx2
8) Confidence 0.41 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.11 Pain Relevance 0.06
However, we found no striking differences in the expression of the mRNAs encoding the cortical patterning factors Emx1 and Emx2 between cortical astroglia cultured adherently or expanded under neurosphere condition (Figure 10H and 10I).
Gene_expression (expression) of Emx2 in patterning
9) Confidence 0.41 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.03
HOXA10 has been demonstrated to be involved in the regulation of pinopode development and expression of other genes involved in endometrial development such as ITGB3 and EMX2 (Bagot et al., 2001; Daftary et al., 2002; Troy et al., 2003).
Gene_expression (expression) of EMX2
10) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
NS cells also express Emx2, which is implicated in expansion of neural precursor cells [53,54] (Figures 5B and S1).
Gene_expression (express) of Emx2 in precursor cells
11) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Emx2
12) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
All NS cells examined express the same panel of radial glia markers (Figures 5A and S2), plus the neural precursor markers Sox2, Sox3, and Emx2, and the bHLH (basic helix–loop helix) transcription factors Olig2 and Mash1 (Figure 5B).
Spec (examined) Gene_expression (express) of Emx2 in neural
13) Confidence 0.18 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
The following oligonucleotide primers were used for the qPCR: Gapdh, Emx1, and Emx2 [34]; Sox2 [77], Ngn2 [78], ?
Gene_expression (used) of Emx2
14) Confidence 0.16 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.09

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