INT1827

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 9.37
Pain Relevance 12.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
neurons 3
neuronal 2
respiratory 2
liver 1
Aap (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1590 100.00 Very High Very High Very High
Bile 1 99.16 Very High Very High Very High
Chronic pancreatitis 2 97.20 Very High Very High Very High
cva 15 88.48 High High
fibrosis 3 87.48 High High
imagery 37 83.04 Quite High
Hippocampus 9 79.52 Quite High
halothane 9 74.96 Quite High
Dopamine 9 71.80 Quite High
Eae 1 62.48 Quite High
Disease Link Frequency Relevance Heat
Urinary Tract Infection 24 99.96 Very High Very High Very High
Infection 7 99.68 Very High Very High Very High
Death 415 99.60 Very High Very High Very High
Injury 56 99.40 Very High Very High Very High
Respiratory Disease 2 98.00 Very High Very High Very High
Toxicity 172 97.24 Very High Very High Very High
Pancreatitis 4 97.20 Very High Very High Very High
Pancreatic Cancer 2 96.20 Very High Very High Very High
Chronic Disease 27 95.68 Very High Very High Very High
Cirrhosis 3 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean (+/- sd) kinetic variables for absorption of AAP from tablets in young and elderly were peak plasma concentration, 11.8 (+/- 4.2) vs 10.9 (+/- 4.1) micrograms/ml; peak time, 0.79 (+/- .54) vs 0.69 (+/- .40) hours after the dose; absorption half-life, 12.6 (+/- 9.8) vs. 8.2 (+/- 5.3) minutes; and absolute systemic availability, 79 (+/- 9) vs 72 (+/- 11) per cent.
Gene_expression (absorption) of AAP in plasma associated with paracetamol
1) Confidence 0.67 Published 1982 Journal J Am Geriatr Soc Section Abstract Doc Link 7069091 Disease Relevance 0 Pain Relevance 0.55
These levels of AAP and its metabolites in patient groups were compared with those in corresponding healthy subject groups.
Gene_expression (levels) of AAP associated with paracetamol
2) Confidence 0.60 Published 1996 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 8832306 Disease Relevance 0.94 Pain Relevance 0.53
Microvascular disturbances and injury may also be relevant for the progression of AAP-induced liver injury.
Gene_expression (progression) of AAP in liver associated with paracetamol and injury
3) Confidence 0.54 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410261 Disease Relevance 1.47 Pain Relevance 0.72
Plasma levels of AAP were determined in blood samples drawn up to 12 hours after the dose.
Gene_expression (levels) of AAP in blood associated with paracetamol
4) Confidence 0.52 Published 1982 Journal J Am Geriatr Soc Section Abstract Doc Link 7069091 Disease Relevance 0 Pain Relevance 0.51
An increased apparent formation rate constant for AAP glucuronidation (135%), in concert with significantly lower apparent formation rate constants for those metabolites which reflect the production of the reactive intermediate from AAP (glutathione and N-acetylcysteine), provide the rationale for this shift of metabolism.
Gene_expression (production) of AAP associated with paracetamol
5) Confidence 0.51 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2038747 Disease Relevance 0.14 Pain Relevance 1.08
The percentages of iv dose excreted in 6 hr bile as AAP-glucuronide, AAP-glutathione, and AAP-cysteine-expressed in terms of AAP-significantly increased in the YH-439 pretreated rats.
Gene_expression (expressed) of AAP in bile associated with paracetamol and bile
6) Confidence 0.50 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8824927 Disease Relevance 0.16 Pain Relevance 1.44
Quantification of total GSH content, in vehicle- and AAP-treated cells for 18 h, showed that AAP reduced GSH levels to 50% of control values in a concentration-dependent manner (Figure 5A).
Gene_expression (reduced) of AAP associated with paracetamol
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.51 Pain Relevance 0.83
These data show that, at least for 3 h, AAP levels that were toxic to rat cortical neurons in vitro were achieved in rat CSF following AAP i.p. administration.
Gene_expression (levels) of AAP in neurons associated with paracetamol
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.33 Pain Relevance 1.20
Moreover, an increase in AAP-mediated ROS levels could also contribute to neuronal damage.
Gene_expression (levels) of AAP-mediated in neuronal associated with paracetamol
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.66 Pain Relevance 0.81
To fulfil this aim, we injected AAP (250 and 500 mg/Kg) i.p. to rats and measured AAP plasma and CSF levels at different times after injection.
Gene_expression (plasma) of AAP in plasma associated with paracetamol
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.33 Pain Relevance 1.09
We thus decided to study ROS production in AAP-treated cortical neurons.
Gene_expression (production) of AAP in neurons associated with paracetamol
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.34 Pain Relevance 0.81
According to this proposed mechanism, NAC, a drug that increases intracellular glutathione levels, prevents AAP-induced neuronal death.
Neg (prevents) Gene_expression (prevents) of AAP in neuronal associated with paracetamol and death
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.90 Pain Relevance 0.55
Quantification of AAP concentration in LCR and plasma obtained from AAP-injected rats
Gene_expression (obtained) of AAP in plasma associated with paracetamol
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.05 Pain Relevance 0.54
In summary, our data indicate that, in rats, AAP produces neuronal death of cortical neurons, both in vivo and in vitro, at the same concentration range.
Gene_expression (produces) of AAP in neurons associated with paracetamol and death
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.84 Pain Relevance 0.65
To summarise, it seems that AAP concentrations up to 100 µM or AAP doses up to 100 mg/Kg prevent ROS production and citotoxicity, but higher doses do not.
Gene_expression (doses) of AAP associated with paracetamol
15) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.61 Pain Relevance 1.12
Phyllis Magrab was director of the Child Development Center at Georgetown University; John McQueen was past president of the AAP; Julie Beckett was mother of a child with severe respiratory disease and responsible for the Katy Beckett amendment where the government paid for home care of these children; Antoinette Eaton from Columbus, Ohio, was president of the AAP.
Gene_expression (president) of AAP in respiratory associated with respiratory disease
16) Confidence 0.14 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2045656 Disease Relevance 0.19 Pain Relevance 0
Phyllis Magrab was director of the Child Development Center at Georgetown University; John McQueen was past president of the AAP; Julie Beckett was mother of a child with severe respiratory disease and responsible for the Katy Beckett amendment where the government paid for home care of these children; Antoinette Eaton from Columbus, Ohio, was president of the AAP.
Gene_expression (president) of AAP in respiratory associated with respiratory disease
17) Confidence 0.14 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2045656 Disease Relevance 0.17 Pain Relevance 0
[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)].
Gene_expression ([Isoenzymes) of AAP in pancreas associated with pancreatic cancer and chronic pancreatitis
18) Confidence 0.08 Published 1975 Journal Clin. Chim. Acta Section Title Doc Link 238768 Disease Relevance 0.79 Pain Relevance 0.19
Fig. 1Graphical representation of VUR prevalence determined from 54 studies weighted by sample size of children with UTI (reproduced with permission from Pediatrics vol. 103, pp 843–52, copyright 1999 by the AAP)
Gene_expression (reproduced) of AAP associated with urinary tract infection
19) Confidence 0.03 Published 2006 Journal Pediatr Radiol Section Body Doc Link PMC2663642 Disease Relevance 0.94 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox