INT182750

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 61
Total Number 61
Disease Relevance 17.23
Pain Relevance 7.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) embryo development (Hmgcr)
Anatomy Link Frequency
amygdala 3
hippocampus 3
cones 3
stroma 2
CGR8 2
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 49 99.92 Very High Very High Very High
imagery 237 99.54 Very High Very High Very High
Hippocampus 698 99.36 Very High Very High Very High
amygdala 641 99.32 Very High Very High Very High
melanocortin 1 receptor 33 98.46 Very High Very High Very High
Bile 4 94.48 High High
Pain 32 93.64 High High
Neuropeptide 16 93.00 High High
substance P 32 92.28 High High
Inflammation 334 91.20 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 263 99.92 Very High Very High Very High
Sprains And Strains 1238 99.78 Very High Very High Very High
Pseudorabies 4 99.22 Very High Very High Very High
Anxiety Disorder 80 98.96 Very High Very High Very High
Cancer 249 98.46 Very High Very High Very High
Neurological Disease 50 98.04 Very High Very High Very High
Stress 172 96.32 Very High Very High Very High
Mental Disorders 48 96.32 Very High Very High Very High
Disorder Of Lipid Metabolism 67 96.16 Very High Very High Very High
Atherosclerosis 98 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4, NV Jade is similar to NV Emerald in its ability to be distinguished spectrally from NV Red and NV Maroon and is quiteompatible with standard optical filters used for confocal and epifluorescence imaging (Table 2).
Gene_expression (distinguished) of NV Red associated with imagery
1) Confidence 0.58 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0 Pain Relevance 0.16
Where bleed through was seen (e.g., in the Cy5 channel used for imaging NV Maroon when bright NV Red labeled fibers were present in the same region), electronic corrections were made in each color channel using Image Pro (Media Cybernetics, Silver Spring, MD) prior to combining them into an RGB image.
Gene_expression (present) of NV Red associated with imagery
2) Confidence 0.58 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.08 Pain Relevance 0.12
Background correction settings used by Image Pro can be generated only if bleed-through is unidirectional (e.g., bright NV Red signal may give some bleed through in the Cy5 filter used to detect NV Maroon, but bright NV Maroon signal does not give bleed through in the Texas Red filter used to detect NV Red).


Gene_expression (detect) of NV Red
3) Confidence 0.58 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.06 Pain Relevance 0.16
Background correction settings used by Image Pro can be generated only if bleed-through is unidirectional (e.g., bright NV Red signal may give some bleed through in the Cy5 filter used to detect NV Maroon, but bright NV Maroon signal does not give bleed through in the Texas Red filter used to detect NV Red).


Gene_expression (detect) of Red
4) Confidence 0.58 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.06 Pain Relevance 0.16
Figure 2a-f and Additional File 1 show the eigengene expression values of the Magenta, Red and Pink modules.
Gene_expression (expression) of Red
5) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.33 Pain Relevance 0.30
The eigengene comparison showed that the Magenta module completely separates the inbred mouse strains, while the Pink and Red modules distinguish the amygdala and hippocampus independent of strain origin.
Gene_expression (modules) of Red in hippocampus associated with hippocampus, sprains and strains and amygdala
6) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.34 Pain Relevance 0.33
Other genes in the Red module are also of added value since they may complement and/or interconnect our knowledge of pathways without having a known, large effect on neuropsychiatric traits directly.
Gene_expression (module) of Red
7) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.19 Pain Relevance 0.47
Of these, Fgf10 and 4930511J11Rik belonged to the Red module.
Gene_expression (module) of Red
8) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.73 Pain Relevance 0.29
Visual inspection of the hierarchical clustering trees shows that this is the case for the Red and Pink modules, but not for the Magenta module (see Additional File 4).
Neg (not) Gene_expression (modules) of Red
9) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.62 Pain Relevance 0.22
The preservation of module eigengene significance of the Red and Pink modules was used to validate these gene networks as enriched with genes differentially expressed between amygdala and hippocampus independent of origin of strain.
Gene_expression (modules) of Red in hippocampus associated with hippocampus, sprains and strains and amygdala
10) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.60 Pain Relevance 0.24
To assess the preservation of the Red and Pink modules, we used a connectivity-based module preservation measure described in [8,25,35].
Gene_expression (modules) of Red
11) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.58 Pain Relevance 0.21
However, the Red module was shown to be enriched with the categories of Neurological Disease, Genetic Disorder and Psychological Disorder, as well as Behavior and Nervous System Processes.
Gene_expression (module) of Red associated with mental disorders and neurological disease
12) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.31 Pain Relevance 0.14
Pink and Red modules) represent biological relevant molecular pathways.
Gene_expression (modules) of Red
13) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.45 Pain Relevance 0.34
Second, our previous work showed that NV Red could be detected in the same spectral window as DiI, the prototypic neurotracing dye, but gave four-fold greater signal at equivalent concentrations (Fritzsch et al., 2005b).


Gene_expression (detected) of NV Red
14) Confidence 0.52 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.08 Pain Relevance 0.11
While Red and Pink modules clearly separate amygdala and hippocampus in these two strains, the functions represented in these modules may extend to other (brain) regions as well.
Gene_expression (modules) of Red in brain associated with hippocampus, sprains and strains and amygdala
15) Confidence 0.46 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.80 Pain Relevance 0.40
In addition, the correlation between the eigengenes for the Red, Pink and Magenta modules with expression values of all probes (i.e.
Gene_expression (eigengenes) of Red
16) Confidence 0.46 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.31 Pain Relevance 0.34
The hybridization artifact is not present in the modules found to be significantly enriched with genes differentially expressed between the amygdala and hippocampus samples in both strains, i.e. the Red and Pink modules (Figures 2, 3, Additional File 2).
Gene_expression (modules) of Red in hippocampus associated with hippocampus, sprains and strains and amygdala
17) Confidence 0.46 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.27 Pain Relevance 0.18
The number of probes containing SNPs did not differ significantly between the Red and Pink modules.
Gene_expression (modules) of Red
18) Confidence 0.46 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.05 Pain Relevance 0
For example, the expression of genes involved in endogenous cholesterol synthesis (for example, HMG-CoA reductase) and cholesterol uptake from plasma (for example, LDLR) is diminished.
Gene_expression (expression) of HMG-CoA reductase in plasma
19) Confidence 0.46 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.28 Pain Relevance 0.23
In addition to synthesizing cholesterol, HMG-CoA reductase also produces a number of non-sterol products.
Gene_expression (synthesizing) of HMG-CoA reductase
20) Confidence 0.19 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.50 Pain Relevance 0.24

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