INT182772

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.89
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKB1, IL1B) signal transduction (NFKB1, IL1B) nucleoplasm (NFKB1)
cell differentiation (ROS1) mitochondrion (NFKB1) aging (IL1B)
ROS1 (Homo sapiens)
NFKB1 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 100.00 Very High Very High Very High
Inflammatory marker 1 99.28 Very High Very High Very High
Osteoarthritis 2 76.44 Quite High
imagery 2 38.04 Quite Low
Inflammation 15 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 100.00 Very High Very High Very High
Atherosclerosis 39 98.70 Very High Very High Very High
Diabetes Mellitus 53 98.38 Very High Very High Very High
Calcification 98 94.16 High High
Metabolic Syndrome 7 87.28 High High
Atherosclerotic Plaque 3 83.84 Quite High
Injury 8 78.12 Quite High
Osteoarthritis 2 76.44 Quite High
Osteoporosis 7 74.96 Quite High
Chronic Renal Failure 45 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In atheroscleropathy and non-diabetic atherosclerosis, the multiple metabolic toxicities and the resultant – parallel ROS, via stimulation of the essential and omnipotent nuclear factor (NFkappaB), which activates the downstream inflammatory mediators TNFalpha, IL-1, IL-6, and other inflammatory markers such as C-reactive protein (CRP).
ROS Positive_regulation (stimulation) of NFkappaB Positive_regulation (activates) of IL-1 associated with inflammatory mediators, atherosclerosis, diabetes mellitus and inflammatory marker
1) Confidence 0.00 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.89 Pain Relevance 0.14

General Comments

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