INT182790

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.18
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (SAE1) nucleus (SAE1) ligase activity (SAE1)
Anatomy Link Frequency
brain 1
SAE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 84.16 Quite High
Pain 12 67.04 Quite High
cytokine 6 19.20 Low Low
tolerance 1 13.84 Low Low
alcohol 1 8.72 Low Low
drug abuse 1 7.84 Low Low
Electroencephalography 6 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Encephalopathy 36 100.00 Very High Very High Very High
Respiratory Failure 1 96.08 Very High Very High Very High
Calcification 98 95.00 High High
Sepsis 40 89.92 High High
Diabetes Mellitus 53 86.40 High High
Apoptosis 7 84.72 Quite High
INFLAMMATION 27 84.16 Quite High
Peripheral Arterial Disease 4 82.16 Quite High
Anorexia 2 72.32 Quite High
Pneumonia 4 65.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If the physician found that the child had experienced an SAE, GSK Biologicals, MVI, and the Local Safety Monitor were promptly notified.


Positive_regulation (experienced) of SAE
1) Confidence 0.49 Published 2007 Journal Trials Section Body Doc Link PMC1847838 Disease Relevance 0.48 Pain Relevance 0.18
We have previously demonstrated that levels of the highly brain-specific protein S100B were increased in low consciousness SAE, suggesting a possible use for this protein as a biomarker of SAE [5].
Positive_regulation (increased) of SAE in brain associated with encephalopathy
2) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.42 Pain Relevance 0.14
Elevated SUA reflects the activity of the xanthine oxidase enzyme and its production of ROS, which subsequently has a positive effect on VOC.
Positive_regulation (Elevated) of SUA associated with calcification
3) Confidence 0.02 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.28 Pain Relevance 0.06

General Comments

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