INT182800

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 10.01
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ETV3) molecular_function (ETV3) biological_process (ETV3)
Anatomy Link Frequency
circulating cells 1
beta cell 1
ETV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 76.72 Quite High
withdrawal 2 74.16 Quite High
tolerance 5 53.28 Quite High
alcohol 6 12.44 Low Low
cytokine 27 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 182 100.00 Very High Very High Very High
Diabetes Mellitus 132 100.00 Very High Very High Very High
Insulin Resistance 32 100.00 Very High Very High Very High
Prediabetic State 4 99.92 Very High Very High Very High
Abdominal Obesity 12 99.56 Very High Very High Very High
Adenoma 38 99.16 Very High Very High Very High
Obesity 31 98.94 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

11 98.24 Very High Very High Very High
Alzheimer's Dementia 2 97.88 Very High Very High Very High
Coagulation Disorder 2 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing levels of obesity, in particular central obesity, are also driving an increase in the prevalence of MetS [3].
Positive_regulation (increase) of MetS associated with abdominal obesity, obesity and metabolic syndrome
1) Confidence 0.46 Published 2008 Journal Int J Behav Nutr Phys Act Section Body Doc Link PMC2582031 Disease Relevance 1.24 Pain Relevance 0
The adjusted OR for adenoma increased as the number of components of MetS increased (p for trend = 0.0001 ).
Positive_regulation (increased) of MetS associated with adenoma and metabolic syndrome
2) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2894746 Disease Relevance 2.77 Pain Relevance 0
Therefore, IS of insulin seems to be impaired at least at the IRS-1 level in MetS.
Positive_regulation (level) of MetS associated with metabolic syndrome
3) Confidence 0.27 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.64 Pain Relevance 0.04
However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen.
Positive_regulation (circulating cells) of MetS in circulating cells associated with necrosis, vascular disease and metabolic syndrome
4) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.87 Pain Relevance 0.08
In addition to insulin and IGF-1, there is another beta cell derived islet hormone that is elevated in IR, metS, prediabetes, and early T2DM termed amylin or islet amyloid polypeptide.
Positive_regulation (elevated) of metS in beta cell associated with diabetes mellitus, alzheimer's dementia, prediabetic state and insulin resistance
5) Confidence 0.15 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.60 Pain Relevance 0
The lipid triad of the metS and T2DM consists of an elevation in VLDL-C or triglycerides, small dense atherogenic LDL-C, and a decrease in HDL-C.
Positive_regulation (elevation) of metS associated with diabetes mellitus and disorder of lipid metabolism
6) Confidence 0.11 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.79 Pain Relevance 0.03

General Comments

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