INT182801

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.92
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CPLX1) transmembrane transport (CPLX1) cytoplasm (CPLX1)
Anatomy Link Frequency
medial 1
CPLX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 66.52 Quite High
Inflammation 15 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calciphylaxis 41 100.00 Very High Very High Very High
Calcification 98 99.54 Very High Very High Very High
Diabetes Mellitus 53 98.32 Very High Very High Very High
Chronic Renal Failure 45 95.86 Very High Very High Very High
Necrosis 6 90.08 High High
Peripheral Arterial Disease 4 86.08 High High
Cv Unclassified Under Development 25 83.52 Quite High
Increased Venous Pressure Under Development 5 81.84 Quite High
Insulin Resistance 6 71.84 Quite High
Metabolic Syndrome 7 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This dual effect of having not only T2DM related medial calcification but also having the increased risk for the development of medial remodeling and VOC from CKD and/or ESRD requiring dialysis would place these individuals at an extremely high risk for the development of excessive medial arterial remodeling and VOC, as well as arteriole remodeling and VOC, which could possibly increase the risk of developing CPLX (figure 2, 7).
Positive_regulation (increase) of CPLX in medial associated with calciphylaxis, calcification, chronic renal failure and diabetes mellitus
1) Confidence 0.04 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.92 Pain Relevance 0.03

General Comments

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