INT182814

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.32
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1, PECAM1) cell adhesion (ICAM1, PECAM1) plasma membrane (ICAM1, PECAM1)
signal transduction (PECAM1)
Anatomy Link Frequency
vascular endothelium 2
leukocyte 1
ICAM1 (Homo sapiens)
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 6 95.40 Very High Very High Very High
cytokine 4 93.60 High High
Inflammation 47 93.20 High High
Inflammatory response 26 88.48 High High
Restless leg syndrome 2 77.36 Quite High
Pain 1 66.12 Quite High
depression 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 35 100.00 Very High Very High Very High
Demyelinating Disease 7 95.40 Very High Very High Very High
INFLAMMATION 73 93.20 High High
Disease Progression 1 92.00 High High
Encephalitis 1 89.56 High High
Paralysis 1 85.68 High High
Amputation 1 85.00 Quite High
Peripheral Arterial Disease 5 83.32 Quite High
Increased Venous Pressure Under Development 8 77.36 Quite High
Pain 1 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This adhesion molecule on the cell surface of phagocytic leukocytes may bind to counter-receptors, such as intercellular adhesion molecule-1 (ICAM-1), present on the surface of vascular endothelium.
ICAM-1 Binding (bind) of adhesion molecule in vascular endothelium associated with adhesions
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.87 Pain Relevance 0.08
This adhesion molecule on the cell surface of phagocytic leukocytes may bind to counter-receptors, such as intercellular adhesion molecule-1 (ICAM-1), present on the surface of vascular endothelium.
adhesion molecule-1 Binding (bind) of adhesion molecule in vascular endothelium associated with adhesions
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.87 Pain Relevance 0.08
Lovastatin treatment also attenuated the transmigration of mononuclear cells by downregulating the expression of leukocyte function antigen-1 (LFA-1), a ligand for intercellular adhesion molecule (ICAM), in endothelial-leukocyte interaction [88] and mononuclear cell infiltration into the CNS has been implicated in MS [89].
ICAM Binding (ligand) of adhesion molecule in leukocyte associated with multiple sclerosis and adhesions
3) Confidence 0.00 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.57 Pain Relevance 0.61

General Comments

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