INT18282

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.31
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
hypothalamus 1
leukocytes 1
SCN 1
brain 1
DMH 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 1 99.96 Very High Very High Very High
Neurotransmitter 4 97.76 Very High Very High Very High
analgesia 25 97.20 Very High Very High Very High
Neuropeptide 2 96.64 Very High Very High Very High
narcan 4 94.64 High High
Raphe 2 94.04 High High
Locus ceruleus 3 92.16 High High
Action potential 1 91.76 High High
Opioid 62 90.60 High High
Enkephalin 4 89.92 High High
Disease Link Frequency Relevance Heat
Respiratory Failure 101 100.00 Very High Very High Very High
Disease 43 100.00 Very High Very High Very High
Injury 9 100.00 Very High Very High Very High
Pulmonary Disease 71 99.00 Very High Very High Very High
Diabetes Mellitus 4 92.08 High High
Obesity 21 81.24 Quite High
Emergencies 3 75.00 Quite High
Pain 82 70.28 Quite High
Hypertension 1 64.56 Quite High
Hyperlipidemia 1 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No statistical interaction was observed for use of high dose NSAIDs or aspirin concomitantly with MHA-SRIs (p = 0.5).
SRI Neg (No) Binding (interaction) of
1) Confidence 0.36 Published 2008 Journal Pharmacoepidemiol Drug Saf Section Body Doc Link 18188866 Disease Relevance 0.06 Pain Relevance 0
Of children, 28% had previously attended with a SRI.
SRI Binding (attended) of associated with injury
2) Confidence 0.32 Published 2005 Journal Eur. J. Pediatr. Section Abstract Doc Link 15812663 Disease Relevance 0.88 Pain Relevance 0.19
In mammals, the SCN in the hypothalamus is the site that controls circadian behavioral rhythmicity (ie, the master clock).6,7 The SCN is synchronized by external stimuli of which the light or dark cycle is the most important (the retina is directly linked to the SCN via the retinohypothalamic tract).
SCN Binding (synchronized) of in hypothalamus
3) Confidence 0.23 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0.25 Pain Relevance 0.85
The generation of rhythmicity in the SCN is genetically determined and based on feedback loop that involves several genes, including Per1, Per2, and Clock.6,7 The SCN and its afferent and efferent pathways contain various neurotransmitters including neuropeptide Y, ?
SCN Binding (genes) of in SCN associated with neurotransmitter and neuropeptide
4) Confidence 0.23 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.92
That the SCN contains a cholinergic marker like ChAT and is responsive to cholinergic agents but does not bind nicotine or ACh reflects a general problem in reconciling functional, physiological, and anatomical markers of neurotransmission.
SCN Neg (not) Binding (bind) of associated with nicotine
5) Confidence 0.21 Published 1990 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 1970231 Disease Relevance 0 Pain Relevance 0.22
Again, FEV1, SRI-SS and leukocytes were independent risk factors (p < 0.05), whereas disease category did not show any more a significant association in this multivariate analysis (p = 0.192).
SRI-SS Neg (not) Binding (association) of in leukocytes associated with respiratory failure and disease
6) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 2.03 Pain Relevance 0
Activity in the VLPO is driven by the SCN via its projections to the vSPZ and DMH (Figure 2) [9].
SCN Binding (projections) of in DMH
7) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0.22
Although previous papers have suggested that restricted feeding does not cause a phase shift of the SCN clock [4], [11], [12], our future studies will examine whether balanced food, substituted food, or simple nutrients can cause a shift of the SCN clock.
SCN Binding (shift) of
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0 Pain Relevance 0
Thus, the mechanisms by which feeding cycles can rapidly entrain peripheral oscillators and allow them to dissociate from the SCN remain unclear.
SCN Binding (dissociate) of
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0.09 Pain Relevance 0.11
CarFIT and MethoFIT showed weaker inhibitory actions on the binding of [3H] DADLE than their parent compounds without SCN-group, but SuperFIT and OMFIT stronger than their parent compounds, 3-methylfentanyl and ohmefentanyl.
SCN Binding (binding) of
10) Confidence 0.02 Published 1999 Journal Life Sci. Section Abstract Doc Link 10574225 Disease Relevance 0 Pain Relevance 0.54
The inhibitory actions of these compounds on binding of [3H]OMF to mouse brain membrane was weaker than those of their parent compounds without SCN-group.
SCN Binding (binding) of in brain
11) Confidence 0.01 Published 1999 Journal Life Sci. Section Abstract Doc Link 10574225 Disease Relevance 0 Pain Relevance 0.55

General Comments

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