INT182830

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 68.88 Quite High
cytokine 2 9.56 Low Low
Inflammation 11 9.20 Low Low
depression 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 99.86 Very High Very High Very High
Alzheimer's Dementia 24 97.98 Very High Very High Very High
Heart Disease 1 95.60 Very High Very High Very High
Disease 75 93.08 High High
Amyloid Plaque 10 91.12 High High
Stroke 9 88.76 High High
Toxicity 12 79.04 Quite High
Dementia 7 71.04 Quite High
Cv General 3 Under Development 2 68.88 Quite High
Coronary Artery Disease 22 57.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Briefly, certain conditions or triggers (eg, genetic influences, aging, etc) predispose APP proteolysis to produce more A?
Negative_regulation (predispose) of Protein_catabolism (proteolysis) of APP associated with aging
1) Confidence 0.35 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.49 Pain Relevance 0
Addition of lovastatin to human HEK cells transfected with the amyloid precursor protein (APP) was shown to reduce intracellular cholesterol/protein ratios by 50%, and to inhibit cleavage of APP by beta-secretase [97].
Negative_regulation (inhibit) of Protein_catabolism (cleavage) of APP in cleavage associated with alzheimer's dementia
2) Confidence 0.24 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.60 Pain Relevance 0.03

General Comments

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