INT182834

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
brain 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 12 100.00 Very High Very High Very High
long-term potentiation 83 99.98 Very High Very High Very High
Anterior cingulate cortex 78 98.04 Very High Very High Very High
Nucleus accumbens 2 78.48 Quite High
Morphine 1 74.56 Quite High
amygdala 3 72.88 Quite High
qutenza 37 5.00 Very Low Very Low Very Low
nMDA receptor 11 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Pyramidal cell 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 12 100.00 Very High Very High Very High
Targeted Disruption 54 90.88 High High
Anxiety Disorder 59 87.84 High High
Stress 2 76.00 Quite High
Appetite Loss 1 64.80 Quite High
Injury 1 50.00 Quite Low
Shock 16 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nuclear location of CaMKIV, its broad distribution in forebrain areas related to pain, attention and emotion, [10,14-18] and its activation of CREB make it an attractive candidate for the processing of higher brain functions.
Positive_regulation (activation) of Localization (location) of CaMKIV in brain associated with pain
1) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.67 Pain Relevance 0.34
Accordingly, it is likely that the LTP induction stimuli readily recruit CaMKIV in membrane compartments, leading to protein synthesis.
Positive_regulation (induction) of Localization (recruit) of CaMKIV associated with long-term potentiation
2) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.65

General Comments

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