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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Anatomy Link Frequency
neuronal 1
Crebbp (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 49 91.88 High High
Morphine 1 87.96 High High
Calcium channel 1 83.80 Quite High
Pain 10 72.56 Quite High
amygdala 4 40.80 Quite Low
long-term potentiation 1 26.16 Quite Low
qutenza 37 5.00 Very Low Very Low Very Low
Eae 18 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 89.40 High High
Anxiety Disorder 90 81.84 Quite High
Appetite Loss 1 78.20 Quite High
Pain 10 72.56 Quite High
Targeted Disruption 15 58.80 Quite High
Injury 1 50.00 Quite Low
Sprains And Strains 1 31.12 Quite Low
Congenital Anomalies 3 28.56 Quite Low
Shock 16 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated CREB recruits the transcriptional co-activator CBP (CREB binding protein) which leads to the activation of CRE (cAMP response element) containing promoters and ultimately to gene expression [9-11].
Phosphorylation (Phosphorylated) of CBP
1) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.57 Pain Relevance 0.32
CaMKIV activates several transcription factors such as ATF-1, MEF2D and NF-kappaB [4-6], and is a key regulator of neuronal gene expression that stimulates transcription through the phosphorylation of the cAMP response element binding protein (CREB) and activation of the CREB co-activator, CREB binding protein (CBP) [2,3,7].
Phosphorylation (phosphorylation) of CBP in neuronal
2) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.21 Pain Relevance 0.22

General Comments

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