INT182839

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)
Camk4 (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 49 95.20 Very High Very High Very High
Neuropeptide 2 91.76 High High
Morphine 1 91.28 High High
Hippocampus 4 80.72 Quite High
amygdala 6 80.08 Quite High
analgesia 15 73.12 Quite High
Pain 10 72.28 Quite High
antidepressant 2 61.52 Quite High
antagonist 1 54.72 Quite High
gABA 1 49.16 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 98.52 Very High Very High Very High
Anxiety Disorder 148 93.48 High High
Stress 37 92.72 High High
Appetite Loss 1 81.52 Quite High
Herpes Simplex Virus 1 78.24 Quite High
Targeted Disruption 18 73.80 Quite High
Pain 10 72.28 Quite High
Injury 1 50.00 Quite Low
Shock 16 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKIV, along with other kinases, activates CREB by phosphorylating it at Ser 133.
CaMKIV Positive_regulation (activates) of CREB
1) Confidence 0.49 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.51 Pain Relevance 0.32
Previous studies have implicated that both CREB [5] and CREM [6] are activated by CaMKIV and both have been shown to play a role in emotional behavior.
CaMKIV Positive_regulation (activated) of CREB
2) Confidence 0.35 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.80 Pain Relevance 0.23
These data suggest that CaMKIV-dependent activation of CREB/CRE signaling pathways is involved in complex behaviour.
CaMKIV Positive_regulation (activation) of CREB
3) Confidence 0.12 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.49 Pain Relevance 0.24

General Comments

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