INT182853

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.48
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 6
neuronal 2
endothelial cells 2
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 32 96.92 Very High Very High Very High
Spinal cord 22 96.72 Very High Very High Very High
Adalimumab 6 92.88 High High
Inflammation 45 90.48 High High
cytokine 26 75.12 Quite High
rheumatoid arthritis 15 72.96 Quite High
Neuropathic pain 29 55.36 Quite High
Arthritis 22 50.00 Quite Low
Etanercept 20 46.44 Quite Low
Pain 19 45.36 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 90 99.14 Very High Very High Very High
Disorder Of Lipid Metabolism 4 95.72 Very High Very High Very High
INFLAMMATION 45 90.48 High High
Rheumatoid Arthritis 15 72.96 Quite High
Infection 24 69.04 Quite High
Histoplasma Infection 6 67.52 Quite High
Herpes Simplex Virus 7 66.24 Quite High
Lumbar Puncture Related Headaches 3 64.48 Quite High
Body Weight 12 63.68 Quite High
Neuropathic Pain 70 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The steady rise in serum anti-TNF after the first injection is intriguing because transgene expression from single-stranded AAV vectors such as tgAAC94 is also progressive.
Negative_regulation (progressive) of Gene_expression (expression) of AAV
1) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.47 Pain Relevance 0.13
AAV mediated transfer of full length Fto cDNA was used for overexpression; ii.) shRNA targeting Fto mRNA for knockdown of gene expression and iii.) two different AAV-controls (empty vector for AAV-Fto and containing a scrambled shRNA sequence for AAV-shRNA).
Negative_regulation (knockdown) of Gene_expression (expression) of AAV
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.45 Pain Relevance 0
Thus, rather than manipulating Fto expression in specific ARC neuronal populations, we chose a strategy employing AAV mediated transfer of Fto cDNA and shRNA coupled with stereotactic injection in order to manipulate Fto expression within the ARC (Fig 1C).


Negative_regulation (employing) of Gene_expression (transfer) of AAV in neuronal associated with aids-related complex
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.87 Pain Relevance 0
At the same time, rAAV1 yielded relatively less GFP expression in stromal keratocytes and endothelial cells than rAAV2 and rAAV5.
Negative_regulation (less) of Gene_expression (expression) of rAAV2 in endothelial cells
4) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2584774 Disease Relevance 0.10 Pain Relevance 0
Transduction of the rabbit corneas with rAAV8 and especially, rAAV1, produced a stronger GFP expression in epithelial cells compared to rAAV5.
Negative_regulation (produced) of Gene_expression (Transduction) of rAAV8 in epithelial cells
5) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2584774 Disease Relevance 0.08 Pain Relevance 0
Transduction of the rabbit corneas with rAAV8 and especially, rAAV1, produced a stronger GFP expression in epithelial cells compared to rAAV5.
Negative_regulation (produced) of Gene_expression (Transduction) of rAAV1 in epithelial cells
6) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2584774 Disease Relevance 0.08 Pain Relevance 0
Transduction of the rabbit corneas with rAAV8 and especially, rAAV1, produced a stronger GFP expression in epithelial cells compared to rAAV5.
Negative_regulation (produced) of Gene_expression (expression) of rAAV5 in epithelial cells
7) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2584774 Disease Relevance 0.08 Pain Relevance 0
This was surprising, given the generally accepted long-term persistence of AAV transgene expression.
Negative_regulation (persistence) of Gene_expression (expression) of AAV
8) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 0.34 Pain Relevance 0.46

General Comments

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