INT182886

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ros1, Mapk8) kinase activity (Ros1, Mapk8) cell differentiation (Ros1)
mitochondrion (Mapk8) cytoplasm (Mapk8) cytosol (Mapk8)
Anatomy Link Frequency
C16 1
Ros1 (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 83.12 Quite High
Kinase C 3 80.52 Quite High
Potency 1 71.96 Quite High
Inflammation 44 45.04 Quite Low
fibrosis 15 28.16 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 33 98.16 Very High Very High Very High
Hepatocellular Cancer 52 96.56 Very High Very High Very High
Insulin Resistance 27 90.40 High High
Cancer 52 90.08 High High
Targeted Disruption 20 87.36 High High
Stress 14 86.28 High High
Death 11 68.24 Quite High
Toxicity 5 64.00 Quite High
Hepatitis B Virus Infection 8 53.68 Quite High
Hepatitis C Virus Infection 8 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sustained JNK activation is induced by ROS by activating upstream MEKKs or inhibiting MKPs [70–72].
ROS Positive_regulation (induced) of JNK
1) Confidence 0.09 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.92 Pain Relevance 0.04
Treating rat H4IIEC3 hepatoma cells with either C18:1 MUFA or C16:0 SFA revealed that palmitic acid, but not oleate, inhibited IRS-2 tyrosine phosphorylation and serine phosphorylation of AKT, through JNK activated by mitochondria-derived ROS [77].
ROS Positive_regulation (activated) of JNK in C16 associated with hepatocellular cancer
2) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.54 Pain Relevance 0.04
intracellular ROS, which may be a sensor to activate JNK.
ROS Positive_regulation (activate) of JNK
3) Confidence 0.01 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.84 Pain Relevance 0.04

General Comments

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