INT182893

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.74
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)
Anatomy Link Frequency
neurons 3
internal 1
soma 1
Sh2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 291 100.00 Very High Very High Very High
dorsal root ganglion 91 100.00 Very High Very High Very High
depression 15 100.00 Very High Very High Very High
anesthesia 4 96.60 Very High Very High Very High
substantia gelatinosa 57 94.08 High High
Calcium channel 10 93.76 High High
tetrodotoxin 5 92.24 High High
Pyramidal cell 24 87.28 High High
c fibre 6 76.88 Quite High
spinal dorsal horn 6 71.68 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 105 100.00 Very High Very High Very High
Depression 15 100.00 Very High Very High Very High
Infection 95 98.60 Very High Very High Very High
Injury 7 97.56 Very High Very High Very High
Body Weight 1 78.64 Quite High
Nociception 37 76.96 Quite High
Pain 38 67.92 Quite High
Dyspepsia 22 50.00 Quite Low
Pseudorabies 5 50.00 Quite Low
Sprains And Strains 40 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant decrease in the Ba2+ current as the mBPAP simulated back-propagating APs recorded further from the soma (Fig. 6c).
Gene_expression (recorded) of APs in soma
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659773 Disease Relevance 0 Pain Relevance 0.24
Recording and analysis of evoked APs
Gene_expression (Recording) of APs associated with action potential
2) Confidence 0.65 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC3009631 Disease Relevance 0.36 Pain Relevance 0.41
We tested this directly using MgGreen AM and found that the increase in internal calcium concentration shows no evidence of significant depression with increasing numbers of APs at 100?
Gene_expression (depression) of APs in internal associated with depression
3) Confidence 0.34 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.19 Pain Relevance 0.45
Action potentials (APs) of colon specific LS DRG neurons were evoked by two times rheobase current stimulation (pulse width: 300 ms) under current clamp conditions.


Gene_expression (neurons) of APs in neurons associated with dorsal root ganglion and action potential
4) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.18 Pain Relevance 0.19
neurons, APs were produced at 0.1 mA and the frequency reached plateau at 0.2 mA.
Gene_expression (produced) of APs in neurons associated with action potential
5) Confidence 0.13 Published 2005 Journal Mol Pain Section Body Doc Link PMC1083421 Disease Relevance 0.15 Pain Relevance 0.40
PRV infected neurons fire APs at elevated rates by 8 hours post infection
Gene_expression (infected) of APs in neurons associated with infection
6) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.64 Pain Relevance 0.26
250 Hz stimulation produced APs in A?
Gene_expression (produced) of APs associated with action potential
7) Confidence 0.10 Published 2005 Journal Mol Pain Section Body Doc Link PMC1083421 Disease Relevance 0.14 Pain Relevance 0.41
Only at higher intensities (> 2 mA), 2000 Hz stimulation produced APs in A?
Gene_expression (produced) of APs associated with action potential
8) Confidence 0.10 Published 2005 Journal Mol Pain Section Body Doc Link PMC1083421 Disease Relevance 0.08 Pain Relevance 0.29

General Comments

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