INT182898

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.49
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Th1 cells 2
brain 2
lung 2
T cells 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 507 100.00 Very High Very High Very High
cytokine 328 100.00 Very High Very High Very High
Dopamine 10 99.76 Very High Very High Very High
rheumatoid arthritis 101 96.40 Very High Very High Very High
fibrosis 239 91.36 High High
chemokine 35 89.28 High High
Acupuncture 56 88.00 High High
withdrawal 4 82.00 Quite High
dexamethasone 24 73.04 Quite High
agonist 9 65.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 488 100.00 Very High Very High Very High
Sprains And Strains 58 99.04 Very High Very High Very High
Fibrosis 199 98.88 Very High Very High Very High
Targeted Disruption 55 98.24 Very High Very High Very High
Rheumatoid Arthritis 117 96.40 Very High Very High Very High
Bacterial Respiratory Disease 2 94.88 High High
Toxicity 6 93.52 High High
Bacterial Infection 6 93.20 High High
Melioidosis 57 92.44 High High
Pulmonary Fibrosis 196 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that Th1 cells are able to produce IL-2 and IFN-?
Regulation (able) of Gene_expression (produce) of IFN in Th1 cells
1) Confidence 0.44 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0.14 Pain Relevance 0.09
Recently, a small subpopulation of skin-homing CD4+ T cells has been identified produced IL-22 as well but lack the production of IL-17 or IFN-?
Regulation (lack) of Gene_expression (production) of IFN in T cells
2) Confidence 0.44 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.38 Pain Relevance 0.06
However, we found no significant differences in the levels of the Th1 cytokines IL-12 and IFN-?
Neg (no) Regulation (differences) of Gene_expression (levels) of IFN associated with cytokine
3) Confidence 0.44 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.13 Pain Relevance 0.26
Correspondingly, in rodents, brain dopamine levels are modulated by peripheral administration of IFN-?
Regulation (modulated) of Gene_expression (administration) of IFN in brain associated with dopamine
4) Confidence 0.44 Published 2008 Journal Biological Psychiatry Section Body Doc Link PMC2885493 Disease Relevance 1.29 Pain Relevance 0.79
The four strains of L. salivarius showed a different ability to modulate production of IFN-?
Regulation (modulate) of Gene_expression (production) of IFN associated with sprains and strains
5) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.32 Pain Relevance 0.12
responses similar to PfCS102, CS 282–318 inducing only weak responses Overall, the frequency of volunteers responding by the production of IFN-?
Regulation (responding) of Gene_expression (production) of IFN
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.17 Pain Relevance 0
Secondly, imiquimod could mediate a better anti-Leishmania Th1 immune response that would result in the production of IFN-?
Regulation (-) of Gene_expression (production) of IFN
7) Confidence 0.44 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710502 Disease Relevance 0.53 Pain Relevance 0
The levels of other cytokines such as IL-2, IL-4, IL-12, IL-13, IL-17, IFN-?
Regulation (levels) of Gene_expression (cytokines) of IFN associated with cytokine
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.35
More recently, we have shown that PI3K, along with CK2, is involved in the classical JAK-STAT pathway of IFN-?
Regulation (classical) of Gene_expression (pathway) of IFN
9) Confidence 0.44 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
The in vitro addition of Bv8 did not affect the production of IL-2 and IFN-?
Neg (not) Regulation (affect) of Gene_expression (production) of IFN
10) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.15 Pain Relevance 0.10
Whereas there was no significant difference between the two groups in the production of IL-2 and IFN?
Neg (no) Regulation (difference) of Gene_expression (production) of IFN
11) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.12 Pain Relevance 0.11
However, each variation pattern was different; the levels of IL-4 and IFN-?
Regulation (different) of Gene_expression (levels) of IFN
12) Confidence 0.44 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.33
No similar effect on the levels of IL-4, IL-13 or IFN-?
Regulation (on) of Gene_expression (levels) of IFN
13) Confidence 0.44 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.97 Pain Relevance 0.42
No similar effect on the levels of IL-4, IL-13 or IFN-?
Regulation (on) of Gene_expression (levels) of IFN
14) Confidence 0.44 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.35 Pain Relevance 0.29
No significant effect of the anti-inflammatory treatments was observed on lung inflammatory parameters as well as cytokine production (IL-10, IL-4, IL-13 and IFN-?)
Neg (No) Regulation (effect) of Gene_expression (production) of IFN in lung associated with inflammation and cytokine
15) Confidence 0.44 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.51 Pain Relevance 0.89
No similar effect on the levels of IL-4, IL-13 or IFN-?
Regulation (on) of Gene_expression (levels) of IFN
16) Confidence 0.44 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.57 Pain Relevance 0.34
Test samples were assessed in triplicate for expression of 18S ribosomal RNA and IFN-?
Regulation (assessed) of Gene_expression (expression) of IFN
17) Confidence 0.44 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.13 Pain Relevance 0.06
Precisely how this occurs and how the defect relates (or is related) to the altered expression of IL-8- and IFN-?
Regulation (altered) of Gene_expression (expression) of IFN
18) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779452 Disease Relevance 0.50 Pain Relevance 0.25

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