INT1829

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 71
Total Number 82
Disease Relevance 64.24
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
adipose tissue 7
plasma 4
fat 3
epithelium 2
blood 2
CFH (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 99.32 Very High Very High Very High
cva 34 99.00 Very High Very High Very High
tolerance 265 98.00 Very High Very High Very High
ganglionectomy 33 97.12 Very High Very High Very High
Inflammation 245 96.28 Very High Very High Very High
abdominal pain 1 94.36 High High
methotrexate 3 88.48 High High
Angina 26 84.48 Quite High
metalloproteinase 28 78.96 Quite High
Somatosensory cortex 1 78.72 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 804 100.00 Very High Very High Very High
Age-related Macular Degeneration 352 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 285 100.00 Very High Very High Very High
Obesity 957 99.98 Very High Very High Very High
Adenocarcinoma 2 99.98 Very High Very High Very High
Flavivirus Infection 880 99.84 Very High Very High Very High
Sprains And Strains 480 99.84 Very High Very High Very High
Insulin Resistance 345 99.80 Very High Very High Very High
Disease 753 99.78 Very High Very High Very High
Infection 596 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CFB gene expression in omental adipose tissue was positively associated with BMI, fasting glucose, and log fasting triglycerides and negatively with HDL cholesterol; CFH gene expression in omental adipose tissue was associated with insulin resistance (Table 3).
Gene_expression (expression) of CFH in adipose tissue associated with obesity, insulin resistance and disorder of lipid metabolism
1) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.03 Pain Relevance 0
CFH gene expression has been reported in mice adipose tissue and nondifferentiated adipocytes but not in association with obesity or insulin resistance (37).
Gene_expression (expression) of CFH in adipose tissue associated with obesity and insulin resistance
2) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.31 Pain Relevance 0.04
Interestingly, the association between CFH gene expression and insulin resistance was only found in the omental fat depot.
Gene_expression (expression) of CFH in fat associated with insulin resistance
3) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.51 Pain Relevance 0.05
CFH gene expression was significantly increased in subcutaneous compared with omental adipose tissue (0.57 ± 0.22 vs. 0.40 ± 0.2 relative units, P = 0.004).
Gene_expression (expression) of CFH in adipose tissue associated with obesity
4) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.82 Pain Relevance 0
To the best of our knowledge, this is the first report demonstrating CFH gene expression in human adipose tissue and circulating fH levels in association with obesity measures.
Gene_expression (expression) of CFH in adipose tissue associated with obesity
5) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.18 Pain Relevance 0.03
Complement CFH gene expression was increased significantly in cells from the SVC fraction of the subcutaneous fat depot than in cells from the SVC fraction of the omental fat depot (0.40 ± 0.19 vs. 0.24 ± 0.02 relative units, P = 0.04).
Gene_expression (expression) of CFH in fat
6) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.85 Pain Relevance 0
This was expected, because the hybrid CFH/CFHL1 gene described here would not be picked up by genomic sequencing using CFH-specific primers

CFH cDNA Sequencing

Gene_expression (picked) of CFH
7) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.14 Pain Relevance 0
In all three, factor H levels were normal and CFH gDNA sequencing had shown normal wild-type sequence, but presence of a hybrid CFH/CFHL1 gene was confirmed by CFH cDNA sequencing.
Gene_expression (levels) of factor H
8) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
In fact, when we analyzed complement factor gene expression according to insulin resistance status, only CFH was significantly more expressed in omental adipose tissue from insulin-resistant subjects (Table 4).


Gene_expression (expressed) of CFH in adipose tissue associated with obesity and insulin resistance
9) Confidence 0.65 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.00 Pain Relevance 0
Both adipose tissue CFH gene expression and circulating fH concentration were significantly associated with insulin resistance and several metabolic parameters (blood pressure, lipid parameters), mainly in AGT subjects.
Gene_expression (expression) of CFH in blood associated with obesity, tolerance and insulin resistance
10) Confidence 0.65 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.41 Pain Relevance 0.05
It is suggested that the variants in this gene influence the levels of CFH expression.
Gene_expression (expression) of CFH
11) Confidence 0.60 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048938 Disease Relevance 0.84 Pain Relevance 0.04
In people with mutations affecting proteins produced by the kidney, a kidney transplant would be likely to work; but in people with mutations affecting factor H, which is produced by the liver, the disease would probably recur after a kidney transplant.


Gene_expression (produced) of factor H in kidney associated with disease
12) Confidence 0.60 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.35 Pain Relevance 0
CFH dosage quotients showed an apparent heterozygous “deletion” of CFH exons 22 and 23 in II:8 (unaffected carrier), III:3 (unaffected carrier), III:6 (affected), and IV:1 (affected).
Gene_expression (exons) of CFH
13) Confidence 0.59 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
To provide further confirmation that the point of recombination responsible for the CFH/CFHL1 hybrid gene lies within the intron between CFH exons 21/22 and CFHL1 exons 4/5, Southern blots were done using a 1.1 kb probe (Figure 6).
Gene_expression (exons) of CFH
14) Confidence 0.59 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
The increased expression of CFH and CFB genes in adipose tissue was observed in the SVF cells (composed by monocytes, fibroblasts, and endothelial cells).
Gene_expression (expression) of CFH in fibroblasts associated with obesity
15) Confidence 0.58 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.38 Pain Relevance 0.08
For the first time, CFH gene expression was detected in human adipose tissue (significantly increased in subcutaneous compared with omental fat).
Gene_expression (expression) of CFH in adipose tissue associated with obesity
16) Confidence 0.58 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.27 Pain Relevance 0.05
Our objective was to study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with obesity and insulin resistance.


Gene_expression (expressions) of CFH in adipose tissue associated with obesity and insulin resistance
17) Confidence 0.58 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 0.99 Pain Relevance 0.03
CFH and CFB gene expressions were evaluated in 76 adipose tissue samples, in isolated adipocytes, and in stromovascular cells (SVC) (n = 13).
Gene_expression (expressions) of CFH in adipocytes associated with obesity
18) Confidence 0.58 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.15 Pain Relevance 0.04
CFH gene expression in omental fat was significantly associated with insulin resistance.
Gene_expression (expression) of CFH in fat associated with insulin resistance
19) Confidence 0.58 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.31 Pain Relevance 0.07
The mutation these researchers identified is likely to result in development of aHUS that does not get better after a kidney transplant, because the abnormal factor H would still be produced in the liver after a transplant had been done.
Gene_expression (produced) of factor H in liver
20) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.27 Pain Relevance 0

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