INT182918

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1, RARA) transcription factor binding (DR1, RARA) nucleoplasm (RARA)
intracellular (DR1) enzyme binding (RARA) DNA binding (DR1)
DR1 (Homo sapiens)
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 14.04 Low Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Bladder Cancer 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Prostatic Intraepithelial Neoplasia 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Confusion 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
DR1 Binding (bound) of RAR
1) Confidence 0.08 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This allows ligand-dependent activation for RXR-RAR heterodimer on DR5, but not on DR1.
DR1 Neg (not) Binding (heterodimer) of RAR
2) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
, resembling the organization of RXR/RAR on DR1 [25] (Figure 1).
DR1 Binding (organization) of RAR
3) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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