INT182931

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR, CDKN1A) nucleus (VDR, CDKN1A) cell morphogenesis (VDR)
DNA binding (VDR) cytoplasm (CDKN1A) cytosol (CDKN1A)
Anatomy Link Frequency
HL-60 2
hematopoietic cells 2
VDR (Homo sapiens)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 40 100.00 Very High Very High Very High
Neuroblastoma 12 75.84 Quite High
Repression 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that p21Cip1 expression is stimulated by both vitamin D and RA in hematopoietic cells (36,37), and therefore this gene constitutes a good model for analyzing the effects of DREAM.
vitamin D Positive_regulation (stimulated) of Gene_expression (expression) of p21Cip1 in hematopoietic cells associated with rheumatoid arthritis
1) Confidence 0.48 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.54 Pain Relevance 0
For these studies, we used hematopoietic HL-60 cells that contain high levels of DREAM (not illustrated), and in which incubation with vitamin D or RA increases p21Cip1 expression and induces differentiation (36,37).
vitamin D Positive_regulation (increases) of Gene_expression (expression) of p21Cip1 in HL-60 associated with rheumatoid arthritis
2) Confidence 0.32 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0

General Comments

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