INT182932

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.58
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PITPNM1, KCNIP3) endoplasmic reticulum (PITPNM1, KCNIP3) cytoplasm (PITPNM1, KCNIP3)
intracellular (PITPNM1) DNA binding (KCNIP3) lipid metabolic process (PITPNM1)
PITPNM1 (Homo sapiens)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
Pain 3 74.16 Quite High
Disease Link Frequency Relevance Heat
Repression 12 93.20 High High
Rheumatoid Arthritis 60 82.84 Quite High
Neuroblastoma 18 80.00 Quite High
Pain 3 74.16 Quite High
Apoptosis 3 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that DREAM binds to DREs as a tetramer may contribute to this flexibility.
DREs Binding (binds) of DREAM
1) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
DREAM (downstream regulatory element antagonist modulator) is a multifunctional Ca2+-binding protein, which acts as a transcriptional repressor by binding as a tetramer to DREs (downstream regulatory elements) located downstream of the TATA box in target genes (1,2).
DREs Binding (binding) of DREAM associated with antagonist
2) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.15 Pain Relevance 0.12
EFmutDREAM binds to DREs and like wild-type DREAM is regulated by cAMP (3).
DREs Binding (binds) of EFmutDREAM
3) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.37 Pain Relevance 0

General Comments

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