INT182940

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (VDR, TNFRSF25) nucleoplasm (VDR) cell morphogenesis (VDR)
DNA binding (VDR) cytosol (TNFRSF25) extracellular region (TNFRSF25)
VDR (Homo sapiens)
TNFRSF25 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 60 92.04 High High
Neuroblastoma 18 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both VDR and RXR were able to interact with the DR3 and, as expected, heterodimerization significantly increased binding.
VDR Binding (interact) of DR3
1) Confidence 0.22 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.05 Pain Relevance 0
To analyze whether DREAM could bind to HREs, gel retardation assays were performed with a probe encompassing a DR3 site, a high-affinity element for RXR/VDR heterodimers.
VDR Binding (element) of DR3 site
2) Confidence 0.19 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.09 Pain Relevance 0
As shown in Figure 9, addition of ligand caused strong recruitment of coactivators by the RXR/VDR heterodimers bound to the DR3, which was shown by the appearance of a super-retarded complex.
VDR Binding (bound) of DR3
3) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0

General Comments

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