INT182943

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1, NR1H4) nucleoplasm (NR1H4) signal transduction (NR1H4)
intracellular (DR1) DNA binding (DR1) transcription factor binding (DR1)
DR1 (Homo sapiens)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 65.52 Quite High
cytokine 6 51.48 Quite High
metalloproteinase 14 50.00 Quite Low
agonist 1 50.00 Quite Low
Arthritis 3 32.60 Quite Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 6 76.72 Quite High
INFLAMMATION 10 65.52 Quite High
Arthritis 5 32.60 Quite Low
Arthropathy 2 31.40 Quite Low
Repression 11 14.20 Low Low
Rheumatoid Arthritis 45 5.00 Very Low Very Low Very Low
Neuroblastoma 12 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, and RXR homodimers bind to the DR-1 element [11], suggesting that all or any of these three dimers may be responsible for mediating the inhibitory effect of LG268 on MMP-1 and MMP-13.
DR-1 element Binding (homodimers) of RXR
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.06
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
DR1 Binding (bound) of RXR
2) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
DR1 Binding (bound) of RXR
3) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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