INT182944

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KCNIP3) endoplasmic reticulum (KCNIP3) DNA binding (KCNIP3)
cytoplasm (KCNIP3) cytosol (KCNIP3) signal transduction (KCNIP3)
HRES1 (Homo sapiens)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 80 95.72 Very High Very High Very High
Repression 16 93.00 High High
Neuroblastoma 24 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyze whether DREAM could bind to HREs, gel retardation assays were performed with a probe encompassing a DR3 site, a high-affinity element for RXR/VDR heterodimers.
HREs Binding (bind) of DREAM
1) Confidence 0.06 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
Our results show that DREAM can bind to HREs and that, unexpectedly, can act as a transcriptional activator and increase ligand-dependent transactivation of constructs containing these motifs, when located upstream the transcription initiation site.
HREs Binding (bind) of DREAM
2) Confidence 0.06 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Although DREAM binds in vitro to the HREs independently of the presence of the occupied receptors, ChIP assays demonstrated that in vivo binding could only be detected upon incubation of cells with the appropriate ligand.
HREs Binding (binds) of DREAM
3) Confidence 0.05 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.18 Pain Relevance 0
Our results show that DREAM can bind to HREs in vitro even more efficiently than to the original DRE from the prodynorphin gene (1).
HREs Binding (bind) of DREAM
4) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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