INT182950

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR, NR1H4) signal transduction (VDR, NR1H4) nucleus (VDR, NR1H4)
cell morphogenesis (VDR) DNA binding (VDR)
VDR (Homo sapiens)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 82 96.80 Very High Very High Very High
Cancer 40 92.96 High High
Apoptosis 20 91.60 High High
Breast Cancer 11 89.52 High High
Prostate Cancer 13 72.28 Quite High
Pancreatic Cancer 2 58.84 Quite High
Acute Promyelocytic Leukemia 1 52.48 Quite High
Bladder Cancer 5 47.36 Quite Low
Transitional Cell Carcinoma 1 37.88 Quite Low
Skin Cancer 21 32.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
VDR Binding (heterodimer) of RXR
1) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Therefore, a combination of reduced binding affinity and abnormal association with coactivators could explain the lack of transcriptional activity of the RXR/VDR heterodimer upon binding to the DRE.
VDR Binding (heterodimer) of RXR
2) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Therefore, a combination of reduced binding affinity and abnormal association with coactivators could explain the lack of transcriptional activity of the RXR/VDR heterodimer upon binding to the DRE.
VDR Binding (heterodimer) of RXR
3) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
VDR Binding (heterodimer) of RXR
4) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
VDR forms heterodimer in association with RXR.
VDR Binding (association) of RXR
5) Confidence 0.01 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.16 Pain Relevance 0

General Comments

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