INT182955

Context Info Confidence 0.03 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleoplasm (VDR, NR1H4) signal transduction (VDR, NR1H4) nucleus (VDR, NR1H4) cell morphogenesis (VDR) DNA binding (VDR)

VDR (Homo sapiens) NR1H4 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 2 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 20 5.00 Neuroblastoma 6 5.00 Repression 4 5.00 Pain 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, a combination of reduced binding affinity and abnormal association with coactivators could explain the lack of transcriptional activity of the RXR/VDR heterodimer upon binding to the DRE.

Positive_regulation (activity) of VDR Binding (heterodimer) of RXR

1) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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