INT182961

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (RARA, KCNIP3) signal transduction (RARA, KCNIP3) nucleus (RARA, KCNIP3)
nucleoplasm (RARA) Golgi apparatus (KCNIP3) endoplasmic reticulum (KCNIP3)
Anatomy Link Frequency
proximal 1
RARA (Homo sapiens)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 40 97.32 Very High Very High Very High
Neuroblastoma 12 71.32 Quite High
Repression 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of DREAM to the proximal RAR?
RAR Binding (Binding) of DREAM in proximal
1) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
RAR Binding (heterodimer) of DREAM associated with rheumatoid arthritis
2) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0

General Comments

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