INT182966

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.12
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
RARA (Homo sapiens)
RARA - L155V (1)
Pain Link Frequency Relevance Heat
agonist 66 100.00 Very High Very High Very High
cytokine 11 98.00 Very High Very High Very High
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 69.52 Quite High
Obesity 1 51.96 Quite High
Repression 4 47.44 Quite Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Experimental Arthritis 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of RAR-selective agonists on IL-1-induced expression of IL-6
Regulation (Effect) of Gene_expression (agonists) of RAR-selective associated with agonist
1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.05 Pain Relevance 0.42
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Regulation (dependent) of Gene_expression (expression) of RAR (L155V)
2) Confidence 0.26 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0

General Comments

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