INT182968

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 15.22
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
macrophages 8
skin 4
monocytes 2
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 64 99.98 Very High Very High Very High
antagonist 27 94.08 High High
cytokine 101 78.04 Quite High
cva 8 56.88 Quite High
headache 11 29.92 Quite Low
cINOD 16 21.80 Low Low
Inflammation 83 21.32 Low Low
Multiple sclerosis 76 5.00 Very Low Very Low Very Low
ketamine 48 5.00 Very Low Very Low Very Low
agonist 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 173 100.00 Very High Very High Very High
Infection 116 100.00 Very High Very High Very High
Dengue 42 100.00 Very High Very High Very High
Prostate Cancer 104 99.84 Very High Very High Very High
Osteogenic Sarcomas 87 99.64 Very High Very High Very High
Apoptosis 228 99.46 Very High Very High Very High
Cancer 531 99.32 Very High Very High Very High
Poisoning 20 99.04 Very High Very High Very High
Disease 125 98.32 Very High Very High Very High
Rheumatoid Arthritis 152 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the affinity of binding of the receptor to the DRE was lower than to a DR3, the CAT activity was also examined after the overexpression of VDR.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of VDR
1) Confidence 0.58 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
Genistein, an isoflavone found in soybeans and a number of plants, in combination with calcitriol, inhibits cell growth in human prostate LNCaP cells, which is dependent on increased expression of p21 and associated with increased VDR expression 60.
Positive_regulation (increased) of Gene_expression (expression) of VDR
2) Confidence 0.56 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.70 Pain Relevance 0
Increased expression of VDR protein, VDR transcriptional activity, and the expression of VDR target genes are also observed in the combination treatment group 61.
Positive_regulation (Increased) of Gene_expression (expression) of VDR
3) Confidence 0.56 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.48 Pain Relevance 0
In addition, binding of in vitro translated DREAM with VDR or RAR fused to GST was analyzed in pull-down assays.
Positive_regulation (translated) of Gene_expression (translated) of VDR
4) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
Expression vectors for VDR and RAR?
Positive_regulation (for) of Gene_expression (Expression) of VDR
5) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Increased expression of VDR protein, VDR transcriptional activity, and the expression of VDR target genes are also observed in the combination treatment group 61.
Positive_regulation (Increased) of Gene_expression (expression) of VDR
6) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.48 Pain Relevance 0
These findings are associated with the observations that Dex enhances VDR expression in SCC cells and VDR ligand binding activities in tumor cell extracts and kidneys but decreases that in intestinal mucosa 53.
Positive_regulation (enhances) of Gene_expression (expression) of VDR associated with cancer, skin cancer and dexamethasone
7) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.11 Pain Relevance 0.23
These findings are associated with the observations that Dex enhances VDR expression in SCC cells and VDR ligand binding activities in tumor cell extracts and kidneys but decreases that in intestinal mucosa 53.
Positive_regulation (enhances) of Gene_expression (expression) of VDR associated with cancer, skin cancer and dexamethasone
8) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.11 Pain Relevance 0.23
Molecular mimicry of naturally phosphorylated human PRL at the major phosphorylation site S179, S179D (PRL), sensitizes relatively vitamin D-insensitive prostate cancer cells DU-145 and PC3 to calcitriol-mediated anti-proliferative effect and apoptosis, which is associated with increased VDR and p21 expression 63.
Positive_regulation (increased) of Gene_expression (expression) of VDR associated with prostate cancer and apoptosis
9) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.51 Pain Relevance 0
An imidazole derivative liarozole inhibits CYP24 activity in prostate cancer cells DU145 and thus sensitizes these cells to calcitriol-mediated growth inhibition, which is associated with increased VDR expression 57.
Positive_regulation (increased) of Gene_expression (expression) of VDR associated with prostate cancer
10) Confidence 0.37 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.96 Pain Relevance 0.08
RRR-alpha-vitamin E succinate (VES), one of the most effective vitamin E forms, induces VDR expression in prostate cancer cells 58.
Positive_regulation (induces) of Gene_expression (expression) of VDR associated with prostate cancer
11) Confidence 0.37 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.98 Pain Relevance 0.07
After transfection, the cells were incubated for 24–36 h in the presence and absence of 100 nM vitamin D (Vit.D) or 1 ?
Positive_regulation (incubated) of Gene_expression (transfection) of vitamin D
12) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
After transfection, the cells were incubated for 24–36 h in the presence and absence of 100 nM vitamin D (Vit.D) or 1 ?
Positive_regulation (transfection) of Gene_expression (transfection) of vitamin D
13) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
Another advantage of UVB exposure in formation of vitamin D is that UVB exposure does not result in excessive production of vitamin D, which causes risks of intoxication.
Neg (not) Positive_regulation (result) of Gene_expression (production) of vitamin D associated with poisoning
14) Confidence 0.35 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.29 Pain Relevance 0
While not framed as such by the user, the search in excerpt one is an attempt at closed discovery, as the concepts “VDR” and “prostate” do not occur together in any document in the database from which EpiphaNet derives its associations.
Neg (not) Positive_regulation (occur) of Gene_expression (prostate) of VDR
15) Confidence 0.31 Published 2010 Journal J Biomed Discov Collab Section Body Doc Link PMC2990276 Disease Relevance 0 Pain Relevance 0
VDR is overexpressed on some OS cell lines and administration of 1, 25-dihydroxyvitamin D3 inhibits tumor growth and metastasis, while promoting terminal differentiation [174, 201].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of VDR associated with cancer, osteogenic sarcomas and metastasis
16) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.56 Pain Relevance 0
These data demonstrated that vitamin D3 affects the crosstalk between tumor cells and macrophages by targeting macrophages and not the tumor cells, and that, accordingly, it requires the expression of VDR on macrophages, consistent with our published data [7].
Positive_regulation (requires) of Gene_expression (expression) of VDR in macrophages associated with cancer
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.17 Pain Relevance 0
It is reported that a person with skin type 5/6 (dark skin) requires 10-50 times the exposure to sunlight to produce the same amount of vitamin D as does a white person with skin type 2/3 [27].


Positive_regulation (requires) of Gene_expression (produce) of vitamin D in skin
18) Confidence 0.23 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.19 Pain Relevance 0
The elderly, due to the decreased presence of skin 7-dehydrocholesterol which is the precursor for UVB mediated synthesis of vitamin D, are particularly at risk of vitamin D deficiency.
Positive_regulation (mediated) of Gene_expression (synthesis) of vitamin D in skin
19) Confidence 0.23 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.45 Pain Relevance 0
Another advantage of UVB exposure in formation of vitamin D is that UVB exposure does not result in excessive production of vitamin D, which causes risks of intoxication.
Positive_regulation (excessive) of Gene_expression (production) of vitamin D associated with poisoning
20) Confidence 0.23 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.29 Pain Relevance 0

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