INT182975

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
SH-SY5Y 1
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 1 89.28 High High
Spinal cord 12 54.40 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
allodynia 3 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 28 95.48 Very High Very High Very High
Lung Cancer 2 26.48 Quite Low
Rheumatoid Arthritis 20 13.52 Low Low
Repression 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the induction of ERK1/2 phosphorylation by ATRA is a RAR-independent key event though which the retinoid increases COX-2 expression and PGE2 production in SH-SY5Y human neuroblastoma cells.
Phosphorylation (phosphorylation) of RAR in SH-SY5Y associated with neuroblastoma
1) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.23 Pain Relevance 0.07
Expression vectors for VDR and RAR?
Phosphorylation (vectors) of RAR
2) Confidence 0.46 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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