INT182976

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 8.49
Pain Relevance 7.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
Anatomy Link Frequency
fibroblasts 1
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 35 100.00 Very High Very High Very High
Pain 254 99.78 Very High Very High Very High
Lasting pain 132 99.76 Very High Very High Very High
Osteoarthritis 308 99.56 Very High Very High Very High
Dynorphin 110 98.80 Very High Very High Very High
Pain score 11 98.32 Very High Very High Very High
Spinal cord 44 96.88 Very High Very High Very High
Pain management 33 95.80 Very High Very High Very High
opiate 11 94.88 High High
Hyperalgesia 11 93.00 High High
Disease Link Frequency Relevance Heat
Repression 59 100.00 Very High Very High Very High
Pain 419 99.78 Very High Very High Very High
Frailty 319 99.56 Very High Very High Very High
Arthritis 55 98.00 Very High Very High Very High
Nociception 33 95.24 Very High Very High Very High
Hyperalgesia 11 93.00 High High
Targeted Disruption 22 89.12 High High
INFLAMMATION 11 88.56 High High
Injury 22 87.76 High High
Neuropathic Pain 11 73.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DREAM mRNA was significantly reduced by 63% in PBMCs from OA patients, with a pain score on the VAS (0 to 100) of greater than 40 (n = 14) compared with healthy controls.
Negative_regulation (reduced) of DREAM associated with pain score and osteoarthritis
1) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.91 Pain Relevance 0.58
We observed minor variations in c-fos expression levels, which could not be attributed to the suppression of DREAM mRNA since the relative expression of c-fos in other non-DREAM siRNA-transfected SFLCs showed similar fluctuations.
Negative_regulation (suppression) of DREAM
2) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.30 Pain Relevance 0.06
Cheng and colleagues [11] demonstrated the effects of the loss of DREAM transcriptional repression in vivo.
Negative_regulation (repression) of DREAM associated with repression
3) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.16 Pain Relevance 0.98
However, the two target genes of DREAM transcriptional repression, pdyn and c-fos, displayed no increase in gene transcription.
Negative_regulation (repression) of DREAM associated with repression
4) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.32 Pain Relevance 0.08
DREAM mRNA was repressed to 25% ± 4% of baseline DREAM expression by siRNA1, 7.6% ± 1.8% by siRNA2, 13% ± 1.3% by siRNA3, 9% ± 0.8% by siRNA4, and 18.8% ± 3.1% by siRNA5.
Negative_regulation (repressed) of DREAM
5) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.51 Pain Relevance 0.43
To inhibit the blocking function of the DREAM protein on pdyn gene expression in SFLCs, five T7 siRNAs were designed and tested (Figure 3a).
Negative_regulation (inhibit) of DREAM protein
6) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.76 Pain Relevance 0.60
Nonetheless, the transcriptional inhibition of DREAM mRNA did not lead to a changed expression of the chosen reporter genes in in vitro experiments using siRNA.
Negative_regulation (inhibition) of DREAM
7) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.89 Pain Relevance 1.11
In vitro and in vivo experiments show a reduction of DREAM mRNA; in both cases, no changes in levels of pdyn mRNA were detected.
Negative_regulation (reduction) of DREAM
8) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.77 Pain Relevance 0.94
In addition, contradicting the theory of DREAM action on pain relief, a reduction of the expression level of DREAM was shown in PBMCs from OA patients with a VAS score of greater than 40 (Figure 2).
Negative_regulation (reduction) of DREAM associated with pain and osteoarthritis
9) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.70 Pain Relevance 0.85
The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements

DREAM (downstream regulatory element antagonist modulator) is a transcriptional repressor, which binds DREs (downstream response elements) in a Ca2+-regulated manner.

Negative_regulation (repressor) of DREAM associated with antagonist
10) Confidence 0.33 Published 2005 Journal Nucleic Acids Research Section Title Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0.05
DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management?


Negative_regulation (reduced) of DREAM in fibroblasts associated with pain, pain management and arthritis
11) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Title Doc Link PMC2483451 Disease Relevance 1.00 Pain Relevance 0.84
The reduction of DREAM and the sustained release of dynorphin could also be a part of an increase in pain perception, similar to the observation that opiate administration paradoxically can induce hyperalgesia [43,44].


Negative_regulation (reduction) of DREAM associated with pain, hyperalgesia, dynorphin and opiate
12) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.11 Pain Relevance 1.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox