INT182983

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 16 99.04 Very High Very High Very High
Rheumatoid Arthritis 80 94.80 High High
Neuroblastoma 24 57.20 Quite High
Apoptosis 4 8.80 Low Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prevalence of protein–protein interactions over binding of DREAM to DNA has been previously reported in the de-repression of DRE sites following cAMP stimulation, which depends on the interaction of DREAM with ?
Positive_regulation (depends) of DREAM Binding (interaction) of associated with repression
1) Confidence 0.54 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.20 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
Positive_regulation (requirements) of DREAM Binding (heterodimer) of associated with rheumatoid arthritis
2) Confidence 0.44 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
HREs are composed of two copies of a hexameric motif rather similar to the DRE, and the presence of two motifs probably contributes to the stabilization of DREAM binding to these sequences.
Positive_regulation (stabilization) of DREAM Binding (binding) of
3) Confidence 0.41 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
It is possible that the concentrations of DREAM used in the retardation assays is sufficient to detect interactions, whereas under physiological conditions DREAM could only be recruited to the promoter through a direct interaction with other proteins.
Positive_regulation (recruited) of DREAM Binding (interaction) of
4) Confidence 0.39 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.15 Pain Relevance 0

General Comments

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