INT182985

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.52
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 305 99.34 Very High Very High Very High
cytokine 45 81.92 Quite High
Inflammatory stimuli 8 58.32 Quite High
Inflammation 59 32.80 Quite Low
rheumatoid arthritis 72 5.00 Very Low Very Low Very Low
Arthritis 44 5.00 Very Low Very Low Very Low
Potency 24 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 80 99.00 Very High Very High Very High
Cancer 133 98.40 Very High Very High Very High
Rheumatoid Arthritis 158 95.64 Very High Very High Very High
Obesity 39 93.56 High High
Breast Cancer 46 91.84 High High
Disease 32 87.52 High High
Esophageal Cancer 1 81.04 Quite High
Osteoarthritis 4 79.44 Quite High
Neuroblastoma 10 78.00 Quite High
Carcinoma 30 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increased the mRNA level of RAR-?
Transcription (level) of RAR
1) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.58
, the mRNA levels of RAR decreased from 30% to 55% for the -?
Transcription (levels) of RAR
2) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.09 Pain Relevance 0.07
The mRNA levels for RAR-?
Transcription (levels) of RAR
3) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.05
In our experimental conditions, we observed that ATRA induced a threefold increase in RAR mRNA levels in IL-1-stimulated cells (data not shown), therefore suggesting that our biological system was suitable to study the pharmacological properties of agonists of RAR or RXR subtypes.
Transcription (levels) of RAR associated with agonist
4) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.14 Pain Relevance 0.42
Downregulation of mRNA expression of RAR?
Transcription (expression) of RAR
5) Confidence 0.42 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.93 Pain Relevance 0
Figure 3C compares the influence of DREAM on the activity of the RAR?
Transcription (activity) of RAR
6) Confidence 0.39 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.55 Pain Relevance 0
modulates the transcriptional activity of RAR [32].
Transcription (activity) of RAR
7) Confidence 0.29 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.94 Pain Relevance 0
processes are critical for the transcriptional activity of RAR/RXR
Transcription (activity) of RAR
8) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.13 Pain Relevance 0
LBD impairs the transcriptional activity of RXR/RAR [21, 22] and RXR/vitamin D3 receptor (VDR) [23].
Transcription (activity) of RAR
9) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0

General Comments

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