INT182990

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
liver 4
RARA (Homo sapiens)
RARA - L155V (1)
Pain Link Frequency Relevance Heat
Inflammation 9 35.52 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 126 99.16 Very High Very High Very High
Rheumatoid Arthritis 86 98.46 Very High Very High Very High
Esophageal Cancer 3 98.16 Very High Very High Very High
Cancer 132 94.92 High High
Metabolic Disorder 18 88.16 High High
Overweight 24 68.08 Quite High
Carcinoma 6 67.56 Quite High
Obesity 105 53.76 Quite High
Body Weight 3 50.00 Quite Low
Repression 16 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, if the expression of RAR correlates with tissue sensitivity to retinoids, our results should be confirmed within a larger number of samples and both the mechanism leading to inappropriate RXR and RAR expression and the response of CRC to retinoids should be investigated.
Positive_regulation (leading) of Gene_expression (expression) of RAR associated with colon cancer
1) Confidence 0.40 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.18 Pain Relevance 0
Similar results were obtained after treatment with RA that did not alter the activity of the prodynorphin promoter even after the overexpression of RAR (Figure 8B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of RAR associated with rheumatoid arthritis
2) Confidence 0.40 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Neg (not) Positive_regulation (activate) of Gene_expression (expression) of RAR (L155V)
3) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
Expression vectors for VDR and RAR?
Positive_regulation (for) of Gene_expression (Expression) of RAR
4) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
In addition, binding of in vitro translated DREAM with VDR or RAR fused to GST was analyzed in pull-down assays.
Positive_regulation (translated) of Gene_expression (translated) of RAR
5) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
On the other hand, while elevated levels of RAR mRNA expression has also been described in breast, liver and esophageal tumors [53,63,64], mechanism and significance are unknown.
Positive_regulation (elevated) of Gene_expression (expression) of RAR mRNA in liver associated with esophageal cancer
6) Confidence 0.27 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.01 Pain Relevance 0
On the other hand, while elevated levels of RAR mRNA expression has also been described in breast, liver and esophageal tumors [53,63,64], mechanism and significance are unknown.
Positive_regulation (levels) of Gene_expression (expression) of RAR mRNA in liver associated with esophageal cancer
7) Confidence 0.27 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.01 Pain Relevance 0

General Comments

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