INT182998

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.28
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 93.04 High High
antagonist 10 74.80 Quite High
Disease Link Frequency Relevance Heat
Pain 5 93.04 High High
Neuroblastoma 30 90.48 High High
Rheumatoid Arthritis 100 89.44 High High
Repression 20 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant DREAM, glutathione S-transferase (GST)-fused VDR and RXR (50–100 ng) and in vitro translated RXR, VDR and RAR were used in the assays with labeled DRE, DR3 and DR5 oligonucleotides as described previously (30).
Localization (used) of DREAM
1) Confidence 0.66 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
Whereas Ca2+ modifies DREAM conformation by binding to the EF-hand motifs, leading to release of DREAM from the DRE (1,5), cAMP-dependent derepression involves a direct protein–protein interaction of DREAM with ?
Localization (release) of DREAM
2) Confidence 0.62 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.17 Pain Relevance 0.12
Stimuli that increase intracellular Ca2+ or cAMP levels cause the release of DREAM from the DRE and transcriptional derepression. cAMP and Ca2+ appear to promote derepression by different mechanisms.
Localization (release) of DREAM
3) Confidence 0.62 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.18 Pain Relevance 0.13
The distance between both elements allows the study of recruitment of DREAM to these elements separately.
Localization (recruitment) of DREAM
4) Confidence 0.58 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0
DREAM is recruited in vivo to HRE-containing promoters in a ligand-dependent manner
Localization (recruited) of DREAM
5) Confidence 0.58 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.54 Pain Relevance 0

General Comments

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