INT183000

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 21
Disease Relevance 12.89
Pain Relevance 9.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
Anatomy Link Frequency
synovial fluid 1
fibroblast 1
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 504 99.64 Very High Very High Very High
Pain 417 99.60 Very High Very High Very High
Lasting pain 216 98.12 Very High Very High Very High
Kappa opioid receptor 144 97.96 Very High Very High Very High
Pain score 18 91.76 High High
Dynorphin 180 84.44 Quite High
Opioid 72 84.04 Quite High
Inflammation 18 83.28 Quite High
antagonist 60 81.92 Quite High
potassium channel 18 81.56 Quite High
Disease Link Frequency Relevance Heat
Repression 102 99.92 Very High Very High Very High
Frailty 522 99.64 Very High Very High Very High
Pain 687 99.60 Very High Very High Very High
Rheumatoid Arthritis 60 98.28 Very High Very High Very High
Alzheimer's Dementia 18 84.80 Quite High
INFLAMMATION 18 83.28 Quite High
Injury 36 82.48 Quite High
Neuroblastoma 18 80.48 Quite High
Nociception 54 75.44 Quite High
Arthritis 90 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DREAM mRNA expression is reduced in osteoarthritis patients with high visual analog scale score
Transcription (expression) of DREAM associated with osteoarthritis
1) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.71 Pain Relevance 0.42
The expression of DREAM mRNA was detectable in 23/26 control subjects and in 23/53 OA patients.
Transcription (expression) of DREAM associated with osteoarthritis
2) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.83 Pain Relevance 0.50
OA patients with a pain intensity of less than or equal to 40 on the VAS (n = 9) displayed no significant reduction in the expression of DREAM mRNA compared with the healthy control group (ANOVA: F (2,43) = 7.91; P < 0.001) (Figure 2).
Transcription (expression) of DREAM associated with pain and osteoarthritis
3) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.97 Pain Relevance 0.68
Here, we present a study on the expression of DREAM mRNA in osteoarthritis (OA) patients and the attempt to inhibit the potential signaling of DREAM in SFLCs using siRNA.
Transcription (expression) of DREAM associated with osteoarthritis
4) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.77 Pain Relevance 0.65
Quantitative expression of DREAM mRNA in OA SFLCs (13.9 ± 0.6; n = 8) was measured using real-time PCR.
Transcription (expression) of DREAM associated with osteoarthritis
5) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.32 Pain Relevance 0.16
The expression of DREAM mRNA was lower in PBMCs (16.46 ± 0.16; n = 19) and synovial fluid cells, which both represent a heterogeneous pool of different cell subpopulations (data not shown).


Transcription (expression) of DREAM in synovial fluid
6) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.57 Pain Relevance 0.31
DREAM activates RARE-dependent transcription
Transcription (transcription) of DREAM
7) Confidence 0.61 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.20 Pain Relevance 0
DREAM mRNA expression was analyzed in PBMCs from both OA patients and healthy controls.
Spec (analyzed) Transcription (expression) of DREAM associated with osteoarthritis
8) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.75 Pain Relevance 0.45
Less DREAM mRNA was detected in the group of patients suffering from strong and persistent pain.
Transcription (detected) of DREAM associated with pain and lasting pain
9) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.68 Pain Relevance 0.87
Detection of DREAM mRNA in synovial fibroblast-like cells and peripheral blood mononuclear cells
Transcription (Detection) of DREAM in fibroblast
10) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.05 Pain Relevance 0.03
Nevertheless, stimulation of HRE-mediated transcription by DREAM and the nuclear receptors appears to have distinct requirements.
Transcription (transcription) of DREAM
11) Confidence 0.53 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.15 Pain Relevance 0
DREAM stimulates VDRE-mediated transcription
Transcription (transcription) of DREAM
12) Confidence 0.53 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
The repression of transcription by DREAM bound to DNA is regulated not only by changes in intracellular concentrations of Ca2+ but also through the interaction with nuclear effector proteins in cAMP signaling [18,19].
Transcription (transcription) of DREAM associated with repression
13) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.66 Pain Relevance 0.52
The expression of DREAM mRNA was shown in both healthy and OA SFLCs as well as PBMCs.
Transcription (expression) of DREAM associated with osteoarthritis
14) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.17 Pain Relevance 0.95
In addition, DREAM mRNA expression was significantly reduced in OA patients with chronic pain (pain intensity as measured by a visual analog scale scale of greater than 40), but no pdyn expression was detectable.


Transcription (expression) of DREAM associated with pain, lasting pain and osteoarthritis
15) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.22 Pain Relevance 0.93
Translation of DREAM mRNA was inhibited by small interfering RNAs (siRNAs).
Transcription (Translation) of DREAM
16) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.17 Pain Relevance 0.97
The expression of DREAM mRNA was detectable in 23/26 control subjects and in 23/53 OA patients.
Transcription (detectable) of DREAM associated with osteoarthritis
17) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.84 Pain Relevance 0.50
The level of DREAM mRNA expression was still reduced to 40.76% ± 6.74% of baseline expression at 72 hours after transfection (Figure 3b).


Transcription (expression) of DREAM
18) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.25 Pain Relevance 0.22
Pre-designed gene-specific primer pairs and probes for quantification of DREAM (Hs00173310_m1) and pdyn (Hs00225770_m1) mRNA levels were used (TaqMan® Gene Expression Assays; Applied Biosystems).
Transcription (levels) of DREAM
19) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.05 Pain Relevance 0
In vitro DREAM transcription could be reduced significantly for more than 48 hours in SFLCs using siRNAs (Figure 3).
Transcription (transcription) of DREAM
20) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.26 Pain Relevance 0.09

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