INT183003

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
Anatomy Link Frequency
SK-N-MC 2
HeLa 2
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 18 98.94 Very High Very High Very High
Rheumatoid Arthritis 60 73.84 Quite High
Repression 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in neuroblastoma SK-N-MC cells, which express high DREAM levels (2), overexpression of DREAM failed to increase basal activity of the DR3-TK-CAT reporter (Figure 2B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of DREAM in SK-N-MC associated with neuroblastoma
1) Confidence 0.62 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.17 Pain Relevance 0
Overexpression of DREAM in GH4C1 cells caused an increase in basal reporter activity, though less pronounced than that observed in HeLa cells that lack this factor, and significantly enhanced the ligand-dependent response (Figure 2B).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of DREAM in HeLa
2) Confidence 0.54 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.16 Pain Relevance 0
In addition, binding of in vitro translated DREAM with VDR or RAR fused to GST was analyzed in pull-down assays.
Positive_regulation (translated) of Gene_expression (translated) of DREAM
3) Confidence 0.44 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0

General Comments

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