INT183005

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (HRES1) cellular_component (HRES1) biological_process (HRES1)
Anatomy Link Frequency
hinge 1
HRES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 56.00 Quite High
agonist 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 133 72.12 Quite High
Body Weight 71 48.64 Quite Low
Cardiovascular Disease 8 24.12 Low Low
Diabetes Mellitus 8 22.80 Low Low
Dyslipidemia /

Combined Dyslipidemia

5 22.12 Low Low
Rheumatoid Arthritis 40 18.28 Low Low
Repression 8 6.72 Low Low
Disorder Of Lipid Metabolism 12 5.00 Very Low Very Low Very Low
Neuroblastoma 12 5.00 Very Low Very Low Very Low
Metabolic Disorder 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptor heterodimers bind to their bona fide HREs with a strict polarity.
HREs Binding (bind) of
1) Confidence 0.06 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Our results show that DREAM can bind to HREs in vitro even more efficiently than to the original DRE from the prodynorphin gene (1).
HREs Binding (bind) of
2) Confidence 0.05 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The D region is a highly flexible hinge region and may be involved in protein-protein interactions, such as receptor dimerization and efficient binding of DBD to HREs.
HREs Binding (binding) of in hinge
3) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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