INT183011

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.94
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
Pain management 6 99.84 Very High Very High Very High
Opioid 8 98.80 Very High Very High Very High
Dynorphin 20 98.52 Very High Very High Very High
opioid receptor 2 98.40 Very High Very High Very High
Kappa opioid receptor 16 98.24 Very High Very High Very High
Lasting pain 24 97.64 Very High Very High Very High
Pain 47 96.20 Very High Very High Very High
Osteoarthritis 56 96.04 Very High Very High Very High
potassium channel 2 69.40 Quite High
Disease Link Frequency Relevance Heat
Repression 14 99.98 Very High Very High Very High
Pain 77 99.84 Very High Very High Very High
Frailty 58 96.04 Very High Very High Very High
Nociception 6 95.52 Very High Very High Very High
Arthritis 10 75.00 Quite High
Alzheimer's Dementia 2 72.64 Quite High
Injury 4 63.12 Quite High
Neuropathic Pain 2 7.00 Low Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies will be needed to identify additional genes in DREAM expressing tissues, which contain HRE-like DREAM binding sites and are regulated by this transcription factor.



Regulation (regulated) of DREAM
1) Confidence 0.35 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
If DREAM is a suitable target in pain management, it might well be the switch to reduce chronic pain in patients suffering from OA.


Regulation (target) of DREAM associated with lasting pain, pain management and osteoarthritis
2) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.01 Pain Relevance 0.69
Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery.


Spec (might) Regulation (effect) of DREAM associated with pain, dynorphin, antagonist, repression and opioid
3) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 0.93 Pain Relevance 0.84

General Comments

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