INT183035

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.21
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FOXA3) nucleus (FOXA3) embryo development (FOXA3)
transcription factor binding (FOXA3)
Anatomy Link Frequency
stage 4 3
foregut 2
stage 3 2
FOXA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 10 89.96 High High
Somatostatin 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 170 99.82 Very High Very High Very High
Hyperinsulinism 20 98.36 Very High Very High Very High
Alzheimer's Dementia 10 90.16 High High
Embryonal Carcinoma 10 79.68 Quite High
Apoptosis 20 75.36 Quite High
Hyperglycemia 10 42.80 Quite Low
Diabetes Mellitus 70 5.00 Very Low Very Low Very Low
Cancer 30 5.00 Very Low Very Low Very Low
Leukemia 20 5.00 Very Low Very Low Very Low
Parkinson's Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We were unable to detect expression of Pdx1 and FoxA3 using immunohistochemical methods in stage 4 IPCs, (data not shown).
Gene_expression (expression) of FoxA3 in stage 4
1) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.30 Pain Relevance 0
To investigate whether RA could stimulate development of NS-derived cells toward an IPC fate, we measured expression of Pdx1, Cdx1, and FoxA3, transcription factors that regulate gastrointestinal organ development [29,30].
Gene_expression (expression) of FoxA3 associated with rheumatoid arthritis
2) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.88 Pain Relevance 0
Thus, tissues derived from neural progenitor cells express insulin, Pdx1, and FoxA3, markers typically co-expressed in foregut-derived tissues.
Gene_expression (express) of FoxA3 in foregut
3) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0
Thus, tissues derived from neural progenitor cells express insulin, Pdx1, and FoxA3, markers typically co-expressed in foregut-derived tissues.
Gene_expression (co-expressed) of FoxA3 in foregut
4) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0
Similarly, we noted that IPC maturation from stage 3 to 4 was accompanied by increased insulin expression, reduced ngn3 expression, and increased or maintained levels of Isl1, FoxA3, and Pdx1 expression (see Figure 1B and 1C).
Gene_expression (expression) of FoxA3 in stage 3 associated with hyperinsulinism
5) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.37 Pain Relevance 0
Pdx1, Cdx1, and FoxA3 expression was induced in “stage 3,” when cell clusters were allowed to adhere to pre-coated wells at a density of 40–80 NSs/cm2 and cultured in low-glucose medium with 2 ?
Gene_expression (expression) of FoxA3 in stage 3
6) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.99 Pain Relevance 0
Coinciding with the onset of high insulin expression levels in mouse islets, ngn3 expression is virtually extinguished [25], while expression of Pdx1, FoxA3, Isl1, and Nkx6.1 in islet ?
Gene_expression (expression) of FoxA3 associated with hyperinsulinism
7) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.33 Pain Relevance 0
Moreover, Shh treatment during stage 4 eliminated expression of Pdx1, FoxA3, and insulin (Figure 3F).
Gene_expression (expression) of FoxA3 in stage 4
8) Confidence 0.62 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.13 Pain Relevance 0
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Gene_expression (expression) of FoxA3 in stage 4
9) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.20 Pain Relevance 0.03
To elucidate the mechanisms underlying RA-induced expression of markers like FoxA3 and Pdx1, we examined Hh signaling during IPC development.
Gene_expression (expression) of FoxA3 associated with rheumatoid arthritis
10) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.28 Pain Relevance 0.04

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