INT183037

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.27
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MNX1)
Anatomy Link Frequency
motoneuron 3
embryos 1
neurons 1
stage 1 1
stage 3 1
MNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 154 98.52 Very High Very High Very High
pain pelvic 3 84.64 Quite High
midbrain 34 81.36 Quite High
Action potential 44 66.24 Quite High
Central nervous system 44 56.00 Quite High
GABAergic 7 50.92 Quite High
Glutamate 58 50.56 Quite High
Dopamine 45 41.88 Quite Low
tetrodotoxin 29 38.48 Quite Low
projection neuron 2 29.44 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 13 96.80 Very High Very High Very High
Rheumatoid Arthritis 153 95.04 Very High Very High Very High
Syndrome 13 95.04 Very High Very High Very High
Osteoarthritis 21 91.12 High High
Malignant Neoplastic Disease 5 85.64 High High
Reprotox - General 3 3 84.64 Quite High
Reprotox - General 1 3 83.36 Quite High
Stress Incontinence 3 80.48 Quite High
Constipation 4 78.80 Quite High
Uterine Fibroids 3 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene responsible for CS is HLXB9 [10,11], which encodes a transcription factor and is expressed in the anterior horn regions of the spinal cord in human embryos.


Gene_expression (expressed) of HLXB9 in embryos associated with spinal cord
1) Confidence 0.53 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481579 Disease Relevance 1.38 Pain Relevance 0.13
Indeed, high expression of HB9 and Chat, and functional expression of cholinergic receptors revealed the spinal motoneuron phenotype of obtained neurons.
Gene_expression (expression) of HB9 in motoneuron
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.49 Pain Relevance 0.10
Interestingly, coordinate expression of all these factors promotes the expression of HB9, the common marker of motoneurons.
Gene_expression (expression) of HB9 in motoneurons
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.39 Pain Relevance 0.07
In stage 3 cultures, Nestin and Ki67 expression was nearly extinguished (see Figure 2), while expression of En1, ngn3, and Hb9 increased (see Figure 1B and 1C).
Gene_expression (expression) of Hb9 in stage 3
4) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0.03
4; Figure 5H, presented in coexpression with HB9), and 76% HoxC8+ cells (76.3±4.4%; n?
Gene_expression (coexpression) of HB9
5) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.44 Pain Relevance 0.04
Indeed, high expression of HB9 and Chat, and functional expression of cholinergic receptors revealed the spinal motoneuron phenotype of obtained neurons.
Gene_expression (expression) of HB9 in motoneuron
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.49 Pain Relevance 0.10
Immunocytological analysis at D42 showed that Tuj1+ cells contained 87% of HB9+ cells (87.3±4.1%; n?
Gene_expression (contained) of HB9
7) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.44 Pain Relevance 0.04
4.4% of cells expressed the MN marker ChAT (Fig. 1h), while Olig 1/2 and HB9 expression decreased significantly (p<0.001; 2+/?
Gene_expression (expression) of HB9
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.03
2.62% of cells expressed the MN marker HB9 (Fig. 1e).
Gene_expression (expressed) of HB9
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.05 Pain Relevance 0
3.6% of cells expressed the MN marker HB9, and no cells expressed the mature MN marker ChAT.
Gene_expression (expressed) of HB9
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.06 Pain Relevance 0
Genes specifying transcription factors essential for in vivo differentiation of lineage-restricted neural progenitors and their differentiated progeny [21,22,23], including En1, Hb9, Isl1, Hoxc6, NRSF/REST, and Nkx6.1, were expressed at low or undetectable levels in stage 1 (see Figure 1B–1C), consistent with the reported multipotency of proliferating NSs grown in high glucose [14].
Gene_expression (expressed) of Hb9 in stage 1
11) Confidence 0.17 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0 Pain Relevance 0
Counting of the positively immunostained neurons showed comparable ratios of the TH+ (<10%) and HB9+ (?
Gene_expression (ratios) of HB9 in neurons
12) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.17 Pain Relevance 0.16

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