INT183038

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.85
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FOXA3) nucleus (FOXA3) embryo development (FOXA3)
transcription factor binding (FOXA3)
Anatomy Link Frequency
stage 3 4
stage 4 2
FOXA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 90.28 High High
Somatostatin 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 68 99.98 Very High Very High Very High
Hyperinsulinism 8 99.16 Very High Very High Very High
Embryonal Carcinoma 4 74.36 Quite High
Apoptosis 8 66.16 Quite High
Alzheimer's Dementia 4 63.20 Quite High
Hyperglycemia 4 26.24 Quite Low
Diabetes Mellitus 28 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the mechanisms underlying RA-induced expression of markers like FoxA3 and Pdx1, we examined Hh signaling during IPC development.
Positive_regulation (induced) of Gene_expression (expression) of FoxA3 associated with rheumatoid arthritis
1) Confidence 0.40 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.28 Pain Relevance 0.05
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Spec (whether) Positive_regulation (required) of Gene_expression (expression) of FoxA3 in stage 4
2) Confidence 0.40 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.20 Pain Relevance 0.03
Pdx1, Cdx1, and FoxA3 expression was induced in “stage 3,” when cell clusters were allowed to adhere to pre-coated wells at a density of 40–80 NSs/cm2 and cultured in low-glucose medium with 2 ?
Positive_regulation (induced) of Gene_expression (expression) of FoxA3 in stage 3
3) Confidence 0.40 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 1.00 Pain Relevance 0
Similarly, we noted that IPC maturation from stage 3 to 4 was accompanied by increased insulin expression, reduced ngn3 expression, and increased or maintained levels of Isl1, FoxA3, and Pdx1 expression (see Figure 1B and 1C).
Positive_regulation (increased) of Gene_expression (expression) of FoxA3 in stage 3 associated with hyperinsulinism
4) Confidence 0.37 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.38 Pain Relevance 0

General Comments

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