INT183042

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HFE) protein complex assembly (HFE) cytoplasm (HFE)
Anatomy Link Frequency
stage 4 1
HFE (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 64.04 Quite High
rheumatoid arthritis 1 61.52 Quite High
spinal inflammation 1 55.32 Quite High
cva 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 6 99.82 Very High Very High Very High
Disease 15 91.92 High High
Rheumatoid Arthritis 18 73.72 Quite High
Diabetes Mellitus 8 68.64 Quite High
Autoimmune Disease 1 60.64 Quite High
Celiac Disease 1 56.64 Quite High
Low Back Pain 1 55.32 Quite High
Sleep Disorders 1 53.04 Quite High
General Immunology 1 50.00 Quite Low
Neonatal Alloimmune Thrombocytopenia 4 30.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then nonclassical class I-like HLA-H, also namely HFE, was identified as a hemochromatosis gene.75 HFE is located approximately 5 megabases telomeric to the HLA-A locus.
Localization (located) of HFE associated with iron overload
1) Confidence 0.56 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.15 Pain Relevance 0.09
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Neg (absence) Localization (absence) of Hh in stage 4
2) Confidence 0.08 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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