INT183046

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 11.14
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 1
hepatocytes 1
muscle 1
brain 1
adipose tissue 1
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 62 99.60 Very High Very High Very High
cytokine 39 97.24 Very High Very High Very High
transdermal 14 96.76 Very High Very High Very High
Inflammation 117 84.72 Quite High
withdrawal 7 84.28 Quite High
Eae 12 75.60 Quite High
Pain 22 72.76 Quite High
sSRI 16 70.32 Quite High
Inflammatory marker 3 62.48 Quite High
antagonist 6 53.68 Quite High
Disease Link Frequency Relevance Heat
Obesity 333 100.00 Very High Very High Very High
Hyperinsulinism 20 100.00 Very High Very High Very High
Repression 1 99.84 Very High Very High Very High
Weight Loss 38 99.72 Very High Very High Very High
Disease 126 99.60 Very High Very High Very High
Stress 27 99.20 Very High Very High Very High
Diabetes Mellitus 642 97.98 Very High Very High Very High
Hypoglycemia 131 96.80 Very High Very High Very High
Critical Illness 11 93.36 High High
Cancer 108 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The similarities between islet cells and neurons are further underscored by the demonstration of insulin gene transcription in the vertebrate brain [5], although it remains unclear whether these vertebrate neurons produce or secrete insulin protein [6].
Transcription (transcription) of insulin in brain
1) Confidence 0.70 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.08 Pain Relevance 0
Semi-quantitative RT-PCR measures of insulin mRNA expression showed that exposure of cultures grown in 5 mM glucose at stage 3 to 17 mM glucose at stage 4 induced insulin expression (Figure 3A).
Transcription (expression) of insulin in stage 4
2) Confidence 0.70 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.16 Pain Relevance 0
methods derive a couple of mathematical equations about the insulin-glucose
Transcription (derive) of insulin-glucose
3) Confidence 0.69 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.15 Pain Relevance 0.07
In the use of an insulin pump, after finishing setting-up, a
Transcription (use) of insulin
4) Confidence 0.69 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.15 Pain Relevance 0
Coinciding with the onset of high insulin expression levels in mouse islets, ngn3 expression is virtually extinguished [25], while expression of Pdx1, FoxA3, Isl1, and Nkx6.1 in islet ?
Transcription (levels) of insulin associated with hyperinsulinism
5) Confidence 0.68 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.34 Pain Relevance 0
However, there was no significant change in proinsulin, Ucp-2 or Gck mRNA expression following 24-h stimulation with AA.
Transcription (expression) of proinsulin
6) Confidence 0.67 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
RT–PCR analysis comparing Srebp-1c, Ppard, Ppara, Ins (proinsulin), Ucp-2, Ampk and Gck mRNA expression in BRIN-BD11 cells treated in the absence or presence of increasing concentrations of AA for 24 h was performed.
Transcription (expression) of proinsulin
7) Confidence 0.67 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Furthermore, a recent report also indicated that while a low-calorie diet substantially enhanced insulin sensitivity (e.g., ?
Transcription (sensitivity) of insulin
8) Confidence 0.63 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 1.16 Pain Relevance 0
Proinsulin levels, while similar at baseline, fell only in the rosi + met group, and were notably lower at 24 weeks, with a significantly different change in levels from baseline compared with the placebo group (P < 0.001, Table 2).
Transcription (levels) of Proinsulin
9) Confidence 0.52 Published 2007 Journal Diabetic Medicine Section Body Doc Link PMC1974817 Disease Relevance 0.25 Pain Relevance 0.04
This data has been confirmed by qPCR indicating that at 21 days there is an insulin mRNA active transcription in conjunction with the highest insulin content/mg total protein ratio.
Transcription (transcription) of insulin
10) Confidence 0.52 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
No clue to the proteolytic activity of the ubiquitin ligases comes from the results for their mRNA expression, which was identical at all insulin concentrations.
Transcription (expression) of insulin
11) Confidence 0.49 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
They found that applied bipolar DC current profiles could enhance the absorption of the insulin and calcitonin.
Transcription (absorption) of insulin
12) Confidence 0.48 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2527667 Disease Relevance 0 Pain Relevance 0.08
First, our analyses are based on single measurements of insulin sensitivity and the respective adipose tissue mRNA expressions, which may not reflect these relationships over time.
Transcription (expressions) of insulin in adipose tissue associated with obesity
13) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.50 Pain Relevance 0.10
In work previously performed on syngeneic murine primary hepatocytes [19], we showed that high glucose concentration stimulated insulin transcription from a bifunctional promoter in p3MTCHins, consisting of the human metallothionein IIA promoter linked to a carbohydrate response element [20], within 6–10 minutes and secretion within 12 minutes.
Transcription (transcription) of insulin in hepatocytes
14) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.39 Pain Relevance 0
For example, diabetes care involves the interaction of nutrition, exercise, stress management, and education—not just the prescription of insulin.
Transcription (prescription) of insulin associated with stress and diabetes mellitus
15) Confidence 0.46 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528566 Disease Relevance 0.43 Pain Relevance 0
Insulin transcription increased 1.5-fold within 5 min in 25 mM glucose, and decreased by about 8-fold within 10 min of restoring glucose concentration to 2.5 mM (Figure 1E).


Transcription (transcription) of Insulin
16) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.24 Pain Relevance 0
Exogenous GLP-1 also stimulates insulin gene transcription and other steps in insulin biosynthesis,37 and, in in vitro studies, has a trophic effect on ?
Transcription (transcription) of insulin
17) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 0.46 Pain Relevance 0.03
During a 2-year period, intra- and postoperative management was similar, except for the blood glucose management: strict glucose control was not implemented until June 2005 and insulin therapy was only initiated after the blood glucose level (BGL) had reached > 150 mg/dL.
Transcription (initiated) of insulin in blood
18) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2646319 Disease Relevance 0.61 Pain Relevance 0
The magnitude of the improvement in insulin sensitivity after weight loss was significantly correlated with decreases in serum A-SAA (

r = ?

Transcription (sensitivity) of insulin associated with weight loss
19) Confidence 0.18 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.98 Pain Relevance 0.27
Its production is inhibited by insulin at the transcription level [22] and is stimulated by glucagon [23], epinephrine [24] and cytokines [25].
Transcription (transcription) of insulin associated with cytokine
20) Confidence 0.15 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox