INT183055

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2005
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 15.54
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTCH1) Golgi apparatus (PTCH1) plasma membrane (PTCH1)
Anatomy Link Frequency
MCF-7 1
stem cell 1
nevus 1
neurite 1
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 3 85.80 High High
Hsan 6 80.40 Quite High
imagery 30 68.32 Quite High
Pain 15 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
local anesthetic 5 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Basal Cell Nevus Syndrome 470 100.00 Very High Very High Very High
Syndrome 200 100.00 Very High Very High Very High
Death 26 99.92 Very High Very High Very High
Medulloblastoma 166 99.76 Very High Very High Very High
Focal Dermal Hypoplasia 10 99.28 Very High Very High Very High
Odontogenic Cysts 120 98.90 Very High Very High Very High
Breast Cancer 330 98.72 Very High Very High Very High
Cancer 402 98.64 Very High Very High Very High
Repression 3 98.44 Very High Very High Very High
Malignant Neoplastic Disease 25 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, immunohistochemical analysis showed reduced expression of PTCH1 due to promoter methylation in BC [26].
Gene_expression (expression) of PTCH1 associated with breast cancer
1) Confidence 0.77 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 2.09 Pain Relevance 0
Compared to XPA, overall frequencies of alterations in PHF2, FANCC and PTCH1 were higher (Figure 4).
Gene_expression (higher) of PTCH1
2) Confidence 0.67 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.48 Pain Relevance 0
Significant association between PTCH1 and XPA deletion in both groups as well as between their methylation in group-B suggested some functional relationship between hedgehog dependent stem cell renewal pathway and the NER pathway.
Gene_expression (deletion) of PTCH1 in stem cell
3) Confidence 0.67 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.38 Pain Relevance 0
Thus an attempt was made in this study to analyze the alterations (deletion, methylation and expression) of PHF2, FANCC, PTCH1 and XPA in early- and late-onset BC of Indian patients and correlate them with clinico-pathological differences.


Spec (analyze) Gene_expression (expression) of PTCH1 associated with breast cancer
4) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 1.40 Pain Relevance 0.08
Table 5 indicates significant association between alterations of FANCC (P = 0.004) and PTCH1 (P = 0.001) genes with their protein expression as seen by immunohistochemistry.
Gene_expression (expression) of PTCH1
5) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0
The mRNA expression of PHF2, FANCC, PTCH1 and XPA in normal breast tissue (n = 6), and primary BC (n = 14) and 1 cell line (MCF-7) was analyzed by quantitative real-time (Q-PCR).
Spec (analyzed) Gene_expression (expression) of PTCH1 in MCF-7 associated with breast cancer
6) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.33 Pain Relevance 0
Gli1 activates Ptc1 expression and thus counters, to some extent Shh repression of Ptc1 activity [33,35,38].
Gene_expression (expression) of Ptc1 associated with repression
7) Confidence 0.50 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.57 Pain Relevance 0
At 300 nM, a dose used to induce neuronal development in ES cell cultures [21], Shh produced a significant increase in neurite outgrowth in NS-derived cells (Figure 3D and 3E; see Methods), and resulted in increased Ptc expression (Figure 3F).
Gene_expression (expression) of Ptc in neurite
8) Confidence 0.43 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.13 Pain Relevance 0
Increased Ptc transcription is a known consequence of Shh signaling, but we did not detect changes of Ptc expression during stages 1–4, consistent with the absence of detectable expression of Hh ligands.
Gene_expression (expression) of Ptc
9) Confidence 0.43 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.22 Pain Relevance 0.03
We detected expression of the Hedgehog receptors Patched (Ptc) and Smoothened (Smo) at all stages (Figure 3B), consistent with the possibility that NS-derived cells are competent for Hh signaling.
Gene_expression (expression) of Ptc
10) Confidence 0.32 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.27 Pain Relevance 0.04
The appearance of two or more recidivant OKCs, or an early OKC in a young subject, is suggestive of NBCCS syndrome.
Gene_expression (syndrome) of NBCCS associated with basal cell nevus syndrome, syndrome and odontogenic cysts
11) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.99 Pain Relevance 0.10
Early onset medulloblastoma may be the presenting sign of NBCCS; thus, in children in which this tumor is diagnosed, NBCCS should be suspected and a careful examination for other signs of the syndrome should be performed in order to rule it out [6].
Gene_expression (presenting) of NBCCS associated with basal cell nevus syndrome, syndrome, cancer and medulloblastoma
12) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 2.47 Pain Relevance 0
Basal cell nevus syndrome, BCNS (OMIM 109400)
Gene_expression (syndrome) of BCNS in nevus associated with basal cell nevus syndrome
13) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 2.31 Pain Relevance 0
NBCCS is caused by mutations in the PTCH1 gene and is transmitted as an autosomal dominant trait with complete penetrance and variable expressivity.
Gene_expression (caused) of NBCCS associated with basal cell nevus syndrome
14) Confidence 0.19 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2607262 Disease Relevance 1.97 Pain Relevance 0
Diagnosis of NBCCS can be made in the presence of two major criteria or one major and two minor criteria [6]:
Gene_expression (made) of NBCCS associated with basal cell nevus syndrome
15) Confidence 0.17 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 1.50 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox