INT183057

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MNX1)
Anatomy Link Frequency
stage 3 2
motoneurons 2
MNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 5 81.88 Quite High
Spinal cord 7 65.84 Quite High
Action potential 6 28.72 Quite Low
repetitive firing 1 9.52 Low Low
Dopamine 9 6.12 Low Low
gABA 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 38 95.32 Very High Very High Very High
Embryonal Carcinoma 1 14.00 Low Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In stage 3 cultures, Nestin and Ki67 expression was nearly extinguished (see Figure 2), while expression of En1, ngn3, and Hb9 increased (see Figure 1B and 1C).
Positive_regulation (increased) of Gene_expression (expression) of Hb9 in stage 3
1) Confidence 0.38 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0.03
Interestingly, coordinate expression of all these factors promotes the expression of HB9, the common marker of motoneurons.
Positive_regulation (promotes) of Gene_expression (expression) of HB9 in motoneurons
2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.39 Pain Relevance 0.07

General Comments

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